Document Detail

Body fat distribution in pre-and post-menopausal women: metabolic and anthropometric variables.
MedLine Citation:
PMID:  12166365     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Abdominal obesity is associated with coronary risk although the causality is not well established. OBJECTIVE: To compare body fat distribution and metabolic variables in obese pre- and post- menopausal women. DESIGN: The study was conducted in 55 obese female subjects (22 pre- and 33 post- menopausal) with body mass indices (BMI) from 27 to 35 Kg/m2. Body fat distribution was measured using waist and hip circumference and computerized tomography. Hormones such as estradiol, testosterone, androstenedione, dehydroepiandrosterone-sulfate, as well as plasma lipids such as triglycerides, total cholesterol, high density lipoprotein, low density lipoprotein, apoproteins A and B, were also determined. RESULTS: No significant differences were found between the two groups in BMI, percentage of body fat, waist circumference, triceps, biceps, suprailiac and abdominal skinfolds. Hip circumference, subscapular skinfold and subcutaneous abdominal adipose tissue area were significantly lower, and waist-hip ratio, visceral area and visceral to subcutaneous area ratios significantly higher in post- menopausal women (P < 0.05). As was expected, basal plasma estrogens, and dehydroepiandrosterone-sulfate, were significantly higher in pre-menopausal women. When comparing plasma lipids, blood cholesterol and low density lipoprotein, values were significantly higher in the post-menopausal group (P < 0.05). CONCLUSIONS: Our data suggest that body fat distribution changes according to menopausal status, with central obesity more pronounced in post- menopausal women. Metabolic abnormalities are related more to visceral adipose tissue and estrogen plasma levels than to BMI.
M Garaulet; F Pérez-Llamas; J C Baraza; M D Garcia-Prieto; P S Fardy; F J Tébar; S Zamora
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journal of nutrition, health & aging     Volume:  6     ISSN:  1279-7707     ISO Abbreviation:  J Nutr Health Aging     Publication Date:  2002  
Date Detail:
Created Date:  2002-08-08     Completed Date:  2002-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100893366     Medline TA:  J Nutr Health Aging     Country:  France    
Other Details:
Languages:  eng     Pagination:  123-6     Citation Subset:  IM    
Dep Physiology, University of Murcia, Spain.
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MeSH Terms
Adipose Tissue / anatomy & histology*
Body Constitution / physiology*
Body Mass Index
Cholesterol / blood
Dehydroepiandrosterone Sulfate / blood
Estrogens / blood
Middle Aged
Obesity / physiopathology
Postmenopause / blood,  metabolism*
Premenopause / blood,  metabolism*
Tomography, X-Ray Computed
Triglycerides / blood
Reg. No./Substance:
0/Estrogens; 0/Triglycerides; 57-88-5/Cholesterol; 651-48-9/Dehydroepiandrosterone Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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