Document Detail

Body fat distribution and early arterial changes in healthy 5-year-old children.
MedLine Citation:
PMID:  21355815     Owner:  NLM     Status:  Publisher    
Abstract Background. It is unknown at what age overweight starts to takes its toll on the vasculature. We studied the relation between body size measures and vascular characteristics in healthy 5-year-old children. Methods. In 306 5-year-old children from an on-going birth cohort, body size characteristics were measured, including sonographic measurement of abdominal fat. Ultrasonographic measurements of the carotid artery were performed to obtain intima-media thickness (CIMT), arterial wall distensibility, and elastic modulus (EM). Results. Increased body-weight was related to thicker CIMT (linear regression coefficient 2.25 ?m/kg; P = 0.003), increased EM (2.73 kPa/kg; P = 0.01), and lower distensibility (?1.23 MPa(?1)/kg; P = 0.03). Similar relations were found for increased BMI with CIMT and EM. Increased intra-abdominal fat was related to thicker CIMT (9.19 ?m/cm; P = 0.02), and increased waist circumference with thicker CIMT (2.17 ?m/cm; P = 0.02), lower distensibility (?1.70 MPa(?1)/cm; P = 0.01), and higher EM (2.77 kPa/cm; P = 0.02), independent of BMI. Conclusion. For the first time it is demonstrated that increased general body mass and particularly waist circumference and intra-abdominal fat are related to thicker and stiffer arteries already early in life.
Caroline C Geerts; Annemieke M V Evelein; Michiel L Bots; Cornelis K van der Ent; Diederick E Grobbee; Cuno S P M Uiterwaal
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-1
Journal Detail:
Title:  Annals of medicine     Volume:  -     ISSN:  1365-2060     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8906388     Medline TA:  Ann Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
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