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Body fat distribution and early arterial changes in healthy 5-year-old children.
MedLine Citation:
PMID:  21355815     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Background. It is unknown at what age overweight starts to takes its toll on the vasculature. We studied the relation between body size measures and vascular characteristics in healthy 5-year-old children. Methods. In 306 5-year-old children from an on-going birth cohort, body size characteristics were measured, including sonographic measurement of abdominal fat. Ultrasonographic measurements of the carotid artery were performed to obtain intima-media thickness (CIMT), arterial wall distensibility, and elastic modulus (EM). Results. Increased body-weight was related to thicker CIMT (linear regression coefficient 2.25 ?m/kg; P = 0.003), increased EM (2.73 kPa/kg; P = 0.01), and lower distensibility (?1.23 MPa(?1)/kg; P = 0.03). Similar relations were found for increased BMI with CIMT and EM. Increased intra-abdominal fat was related to thicker CIMT (9.19 ?m/cm; P = 0.02), and increased waist circumference with thicker CIMT (2.17 ?m/cm; P = 0.02), lower distensibility (?1.70 MPa(?1)/cm; P = 0.01), and higher EM (2.77 kPa/cm; P = 0.02), independent of BMI. Conclusion. For the first time it is demonstrated that increased general body mass and particularly waist circumference and intra-abdominal fat are related to thicker and stiffer arteries already early in life.
Authors:
Caroline C Geerts; Annemieke M V Evelein; Michiel L Bots; Cornelis K van der Ent; Diederick E Grobbee; Cuno S P M Uiterwaal
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-1
Journal Detail:
Title:  Annals of medicine     Volume:  -     ISSN:  1365-2060     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8906388     Medline TA:  Ann Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
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