Document Detail


Body fat at birth and cord blood levels of insulin, adiponectin, leptin, and insulin-like growth factor-I in small-for-gestational-age infants.
MedLine Citation:
PMID:  16624648     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Low birthweight has been associated with an increased risk of obesity, insulin resistance, and diabetes in adulthood. The aim of this study was to evaluate IGF-I, adiponectin, insulin levels, and body fat in small-for-gestational-age (SGA) infants at birth. METHODS: We performed a transverse comparative study in SGA and appropriate-for-gestational-age (AGA) infants. The study was conducted at the Hospital of Gynecology and Obstetrics in Leon, Mexico. Weight, length, and percent of body fat were evaluated during the first 48 h of birth. Glucose, insulin, leptin, adiponectin, and IGF-I levels in cord blood were measured. RESULTS: We studied 100 infants (50 SGA and 50 AGA). A history of diabetes in a second-degree relative was higher in SGA infants than in AGA infants (48.0 vs. 30.0%, respectively; p = 0.03). Glucose, adiponectin, insulin and IGF-I levels were similar between the groups. Leptin levels and percentage of body fat were lower in SGA than AGA (15.3 vs. 23.4 ng/mL; p = 0.003, 11.1 vs. 12.7%; p <0.001, respectively). Logistic regression analysis showed that length, percentage of body fat, and leptin levels were positively associated with birthweight. However, leptin levels were not independent of percentage of body fat. CONCLUSIONS: Low body fat and leptin levels, but no evidence of increased metabolic risk at birth, were found in SGA infants.
Authors:
Claudia Martínez-Cordero; Norma Amador-Licona; Juan Manuel Guízar-Mendoza; Javier Hernández-Méndez; Guillermo Ruelas-Orozco
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of medical research     Volume:  37     ISSN:  0188-4409     ISO Abbreviation:  Arch. Med. Res.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-20     Completed Date:  2006-06-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9312706     Medline TA:  Arch Med Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  490-4     Citation Subset:  IM    
Affiliation:
Departamento de Nutrición, UMAE, León, Guanajuato, Mexico.
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MeSH Terms
Descriptor/Qualifier:
Adiponectin / blood*
Adiposity / physiology*
Adult
Birth Weight
Fats
Female
Fetal Blood / metabolism*
Gestational Age
Humans
Infant, Low Birth Weight / blood*,  physiology*
Infant, Newborn
Insulin / blood*
Insulin-Like Growth Factor I / metabolism*
Leptin / blood*
Chemical
Reg. No./Substance:
0/Adiponectin; 0/Fats; 0/Leptin; 11061-68-0/Insulin; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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