| Body cooling causes normalization of cardiac protein expression and function in a rat heatstroke model. | |
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MedLine Citation:
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PMID: 18823141 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiac dysfunction contributes to heatstroke genesis, which can be ameliorated by whole body cooling. A comparative analysis using two-dimensional in-gel electrophoresis of cardiac protein patterns is performed in rat controls, untreated heatstroke rats, and whole body cooling-treated heatstroke rats. After the onset of heatstroke, animals display hypotension and altered cardiac protein profiles, which can be reversed by whole body cooling. Thus, the proteomic mechanisms exerted by body cooling during heatstroke are elucidated by the current results. |
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Authors:
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Bor-Chih Cheng; Ching-Ping Chang; Yeou-Guang Tsay; Ting-Feng Wu; Chiung-Yueh Hsu; Mao-Tsun Lin |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-09-30 |
Journal Detail:
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Title: Journal of proteome research Volume: 7 ISSN: 1535-3893 ISO Abbreviation: J. Proteome Res. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-11-07 Completed Date: 2009-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101128775 Medline TA: J Proteome Res Country: United States |
Other Details:
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Languages: eng Pagination: 4935-45 Citation Subset: IM |
Affiliation:
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Department of Surgery and Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Heat Stroke / etiology, physiopathology* Hypothermia, Induced / methods* Models, Animal* Myocardium / metabolism* Proteome / metabolism* Proteomics / methods Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Proteome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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