Document Detail

Body composition of patients with Alzheimer's disease.
MedLine Citation:
PMID:  8417092     Owner:  NLM     Status:  MEDLINE    
Low body weight is frequently reported in patients with Alzheimer's disease. We sought to discover why by comparing the body composition of 28 cognitively normal elders and 23 institutionalized individuals with Alzheimer's disease. Body mass index was calculated from standing height and weight. Percentages of lean body mass, body fat, and body water were derived from bioimpedance measurements of resistance and reactance. Skinfold thickness was measured at seven body sites to estimate regional fat distribution. Variables were analyzed by analysis of variance with subjects grouped by cognitive status within gender. Activity level and age were not significant covariates. Both women and men with Alzheimer's disease weighed less than control subjects. Differences in body composition were more pronounced in women with Alzheimer's disease, who had lower body mass index (22.0 +/- 3.0 vs 26.1 +/- 5.1), higher percentage of lean body mass (73.8 +/- 5.1 vs 66.9 +/- 6.5), lower percentage of body fat (26.1 +/- 5.1 vs 33.1 +/- 6.5), and higher percentage of body water (55.8 +/- 5.0 vs 49.3 +/- 6.5) compared with control women. Except for lower body weight, the body composition of men with Alzheimer's disease was not significantly different from that of control men. Patients of both sexes with Alzheimer's disease had less truncal body fat compared with controls, which gave them a youthful body habitus. These differences were not accounted for by age, diet, or activity. Our findings indicate that patients with Alzheimer's disease have lower body weight and may require higher energy intake than cognitively normal elders.
M J Renvall; A A Spindler; J F Nichols; J W Ramsdell
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the American Dietetic Association     Volume:  93     ISSN:  0002-8223     ISO Abbreviation:  J Am Diet Assoc     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-01-22     Completed Date:  1993-01-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7503061     Medline TA:  J Am Diet Assoc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  47-52     Citation Subset:  AIM; IM    
Division of General Internal Medicine/Geriatrics, University of California, San Diego 92103-8415.
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MeSH Terms
Adipose Tissue / pathology*
Alzheimer Disease / pathology*
Body Composition*
Body Weight*
Middle Aged
Motor Activity
Sex Factors
Skinfold Thickness
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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