Document Detail

Body composition, intraerythrocyte sodium content, volume regulation and blood pressure during moderate sodium restriction in hypertensive men.
MedLine Citation:
PMID:  3716879     Owner:  NLM     Status:  MEDLINE    
Eleven moderately obese middle-aged male outpatients with untreated mild hypertension reduced their sodium intake by about 120 mmol per day during 4-6 weeks. Diastolic blood pressure was then significantly reduced in comparison with a matched control group. The reduction of urinary sodium excretion was significantly correlated to the change in mean arterial pressure. Mean body mass showed a small significant decrease, although there were no significant changes in total body water or body fat as determined from measurements of 40K and tritiated water. Nor did mean extracellular water or plasma volume (Evan's blue) show any significant change. The decrease in urinary sodium excretion was associated with increases in plasma renin activity and urinary aldosterone excretion, while a sympathetic nervous natriuretic index (urinary dopamine to noradrenaline excretion ratio) decreased. The low sodium diet period was followed by a period of energy reduction as well as sodium restriction for 15 weeks. Mean body mass was then reduced by about 8 kg. The systolic but not the diastolic blood pressure showed a significant decrease. The intraerythrocyte content of water, sodium and potassium did not change significantly during any of the diet periods. We conclude that moderate sodium restriction lowered the blood pressure and affected the renin-aldosterone and sympathetic nervous system to retain sodium which might explain the constancy of the plasma volume.
B Fagerberg; B Isaksson; H Herlitz; O K Andersson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta medica Scandinavica     Volume:  219     ISSN:  0001-6101     ISO Abbreviation:  Acta Med Scand     Publication Date:  1986  
Date Detail:
Created Date:  1986-07-22     Completed Date:  1986-07-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370330     Medline TA:  Acta Med Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  371-9     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Body Composition*
Diet, Sodium-Restricted*
Erythrocytes / metabolism*
Hypertension / blood,  diet therapy*,  physiopathology
Middle Aged
Obesity / complications
Plasma Volume*
Renin-Angiotensin System
Sodium / blood*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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