| Body composition and hormonal effects following exposure to mycotoxin deoxynivalenol in the high-fat diet-induced obese mouse. | |
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MedLine Citation:
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PMID: 21538849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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SCOPE: To characterize the effects of ingesting the common foodborne mycotoxin deoxynivalenol (DON) on body weight and composition in the high-fat (HF) diet-induced obese mice, a model of human obesity. METHODS AND RESULTS: Female B6C3F1 mice were initially fed HF diets containing 45% kcal (HF45) or 60% kcal (HF60) as fat for 94 days to induce obesity. Half of each group was either continued on unamended HF diets or fed HF diets containing 10 mg/kg DON (DON-HF45 or DON-HF60) for another 54 days. Additional control mice were fed a low-fat (LF) diet containing 10% kcal as fat for the entire 148-day period. DON induced rapid decreases in body weights and fat mass, which stabilized to those of the LF control within 11 days. These effects corresponded closely to a robust transient decrease in food consumption. While lean body mass did not decline in DON-fed groups, further increases were suppressed. DON exposure reduced plasma insulin, leptin, insulin-like growth factor 1, and insulin-like growth factor acid labile subunit as well as increased hypothalamic mRNA level of the orexigenic agouti-related protein. CONCLUSION: DON-mediated effects on body weight, fat mass, food intake, and hormonal levels in obese mice were consistent with a state of chronic energy restriction. |
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Authors:
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Kazuo Kobayashi-Hattori; Chidozie J Amuzie; Brenna M Flannery; James J Pestka |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2011-05-02 |
Journal Detail:
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Title: Molecular nutrition & food research Volume: 55 ISSN: 1613-4133 ISO Abbreviation: Mol Nutr Food Res Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-04 Completed Date: 2011-10-25 Revised Date: 2012-04-12 |
Medline Journal Info:
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Nlm Unique ID: 101231818 Medline TA: Mol Nutr Food Res Country: Germany |
Other Details:
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Languages: eng Pagination: 1070-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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drug effects Agouti-Related Protein / drug effects, genetics Animals Body Composition / drug effects* Body Weight / drug effects* Carrier Proteins / blood, drug effects Dietary Fats / toxicity Eating / drug effects Energy Intake / drug effects Female Glycoproteins / blood, drug effects Hypothalamus / drug effects, physiology Insulin / blood Insulin-Like Growth Factor I / drug effects Leptin / blood Mice Mice, Obese Obesity / chemically induced, drug therapy, metabolism* RNA, Messenger Trichothecenes / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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ES 3358/ES/NIEHS NIH HHS; R01 ES003358-26/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Agouti-Related Protein; 0/Agrp protein, mouse; 0/Carrier Proteins; 0/Dietary Fats; 0/Glycoproteins; 0/Insulin; 0/Leptin; 0/RNA, Messenger; 0/Trichothecenes; 0/insulin-like growth factor binding protein, acid labile subunit; 0/insulin-like growth factor-1, mouse; 51481-10-8/deoxynivalenol; 67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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