Document Detail

Body composition changes in hypertensive subjects on long-term oral diuretic therapy.
MedLine Citation:
PMID:  5440546     Owner:  NLM     Status:  MEDLINE    
Hypertensive patients were treated with either chlorthalidone or frusemide for periods of two to four months. Reduction in blood pressure was seen with chlorthalidone but not with frusemide. This hypotensive effect appeared to be independent of the natriuretic effect.A significant reduction in total exchangeable potassium (K(E)) was seen with both agents, but no patient showed adverse symptoms or signs. There was no alteration in maximal urinary concentration or acidification, or in intravenous glucose tolerance or plasma insulin. It is concluded that potassium depletion of this degree does not require replacement therapy on a routine basis in hypertensive patients.
J J Healy; T J McKenna; B S Canning; T G Brien; G J Duffy; F P Muldowney
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British medical journal     Volume:  1     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1970 Mar 
Date Detail:
Created Date:  1970-06-05     Completed Date:  1970-06-05     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  716-9     Citation Subset:  AIM; IM    
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MeSH Terms
Body Composition*
Chlorthalidone / administration & dosage*
Furosemide / administration & dosage*
Glucose Tolerance Test
Hydrogen-Ion Concentration
Hypertension / drug therapy*
Insulin / blood
Middle Aged
Potassium / metabolism,  urine
Potassium Isotopes
Sodium Isotopes
Reg. No./Substance:
0/Potassium Isotopes; 0/Sodium Isotopes; 11061-68-0/Insulin; 54-31-9/Furosemide; 7440-09-7/Potassium; 77-36-1/Chlorthalidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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