Document Detail


Body composition and bone mineral density in premenopausal and early perimenopausal women.
MedLine Citation:
PMID:  8592954     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Body composition appears to be an important determinant of bone mineral density (BMD). BMD at the femoral neck, lumbar spine, and whole-body and the whole-body soft-tissue composition were measured cross-sectionally in 334 healthy premenopausal and early perimenopausal women, aged 44-50 years, using a Hologic QDR densitometer. Correlations between lean mass and BMD at the hip, spine, and whole-body were greater (r = 0.40, r = 0.44, and r = 0.45, respectively, p < 0.0001) than those for fat mass (r = 0.19, r = 0.16, and r = 0.16, respectively, p < 0.01). There was a significant linear trend in femoral BMD from the lowest to highest category of lean mass (0.75 +/- 0.10 g/cm2, 0.80 +/- 0.10 g/cm2, and 0.86 +/- 0.09 g/cm2, p < 0.0001). Similar trends were demonstrated for spinal and whole-body density. For categories of fat mass, there was a significant linear trend at the hip (0.78 +/- 0.10 g/cm2, 0.79 +/- 0.10 g/cm2, and 0.83 +/- 0.10 g/cm2, p = 0.0106), but not at the spine or whole body. There was a 5.00% (3.62, 6.38; 95% confidence limits) difference in hip BMD per unit (standard deviation) of lean mass, while only a 0.73% (-0.66, 2.11) difference in hiP BMD per unit (SD) of fat mass. Differences in BMD were examined by categories of lean and fat mass (low, medium, high) for a total of nine possible combinations of lean and fat measures. BMD at the hip, spine, and whole-body were significantly higher in those with high lean mass than in those with low lean mass, irrespective of fat mass. Women with high lean/low fat had similar hip, spinal, and whole-body BMD as those with high lean/high fat, despite their significantly lower body weight (62.5 +/- 3.3 kg vs 85.7 +/- 5.4 kg, respectively, p < 0.0001). In premenopausal and early perimenopausal women, body weight alone may not be associated with increased bone mass unless a significant proportion of that weight is comprised of lean mass. The stronger association between lean mass and BMD than that for fat mass may be attributed to differences in determinants of lean mass, such as exercise, lifestyle factors, estrogen levels, or a combination of these factors.
Authors:
L M Salamone; N Glynn; D Black; R S Epstein; L Palermo; E Meilahn; L H Kuller; J A Cauley
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research     Volume:  10     ISSN:  0884-0431     ISO Abbreviation:  J. Bone Miner. Res.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-04-03     Completed Date:  1996-04-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8610640     Medline TA:  J Bone Miner Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1762-8     Citation Subset:  IM    
Affiliation:
University of Pittsburgh, Graduate School of Public Health, Department of Epidemiology, Pennsylvania, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Body Composition / physiology*
Bone Density / physiology*
Cohort Studies
Cross-Sectional Studies
Estrogens / blood
European Continental Ancestry Group
Female
Hip / physiology
Humans
Life Style
Middle Aged
Physical Fitness
Premenopause / physiology*
Spine / physiology
Grant Support
ID/Acronym/Agency:
HL45167/HL/NHLBI NIH HHS; T32AG00181/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Estrogens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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