Document Detail

Body burdens of mercury, lead, selenium and copper among Baltimore newborns.
MedLine Citation:
PMID:  21277575     Owner:  NLM     Status:  MEDLINE    
Umbilical cord blood or serum concentrations of mercury, lead, selenium and copper were measured with inductively coupled plasma mass spectrometry in a population of 300 infants born in Baltimore, Maryland. Geometric mean values were 1.37 μg/L (95% confidence interval: 1.27, 1.48) for mercury; 0.66 μg/dL (95% CI: 0.61, 0.71) for lead; and 38.62 μg/dL (95% CI: 36.73, 40.61) for copper. Mean selenium was 70.10 μg/L (95% CI: 68.69, 70.52). Mercury, selenium and copper levels were within exposure ranges reported among similar populations, whereas the distribution of lead levels was lower than prior reports; only one infant had a cord blood lead above 10 μg/dL. Levels of selenium were significantly correlated with concentrations of lead (Spearman's ρ=0.20) and copper (Spearman's ρ=0.51). Multivariable analyses identified a number of factors associated with one of more of these exposures. These included: increase in maternal age (increased lead); Asian mothers (increased mercury and lead, decreased selenium and copper); higher umbilical cord serum n-3 fatty acids (increased mercury, selenium and copper), mothers using Medicaid (increased lead); increasing gestational age (increased copper); increasing birthweight (increased selenium); older neighborhood housing stock (increased lead and selenium); and maternal smoking (increased lead). This work provides additional information about contemporary prenatal element exposures and can help identify groups at risk of atypical exposures.
Ellen M Wells; Jeffery M Jarrett; Yu Hong Lin; Kathleen L Caldwell; Joseph R Hibbeln; Benjamin J Apelberg; Julie Herbstman; Rolf U Halden; Frank R Witter; Lynn R Goldman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.     Date:  2011-01-31
Journal Detail:
Title:  Environmental research     Volume:  111     ISSN:  1096-0953     ISO Abbreviation:  Environ. Res.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-25     Completed Date:  2011-06-14     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  411-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.
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MeSH Terms
Body Burden
Copper / blood*
Cross-Sectional Studies
Fatty Acids, Omega-3 / blood*
Fetal Blood / chemistry*
Infant, Newborn / blood*
Lead / blood*
Maternal Exposure / adverse effects
Mercury / blood*
Selenium / blood*
Socioeconomic Factors
Statistics, Nonparametric
Urban Population
Young Adult
Grant Support
Reg. No./Substance:
0/Fatty Acids, Omega-3; 7439-92-1/Lead; 7439-97-6/Mercury; 7440-50-8/Copper; 7782-49-2/Selenium

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