Document Detail

Body burden profiles of single and mixed solvent exposures.
MedLine Citation:
PMID:  3681498     Owner:  NLM     Status:  MEDLINE    
The dynamics of inhaled solvents have not been studied extensively for exposure conditions involving combinations of chemical agents. An ongoing laboratory study examining psychomotor performance effects on human volunteers exposed to spray paint agents offered an opportunity to gather data on the body burden profiles produced by the inhalation of two solvents alone and in combination. Breath and blood samples were collected from 70 male and female subjects who were randomly assigned to four treatment conditions: chemical placebo, 250 ppm acetone, 200 ppm methyl ethyl ketone, or 125 ppm acetone/100 ppm methyl ethyl ketone. The exposures lasted for four hours. No interaction between the two solvents affecting uptake or elimination was noted. There were no significant differences between the uptake and elimination in males and females. The results are discussed in relation to physiological simulation modeling of the exposure.
W D Brown; J V Setzer; R B Dick; F C Phipps; L K Lowry
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of occupational medicine. : official publication of the Industrial Medical Association     Volume:  29     ISSN:  0096-1736     ISO Abbreviation:  J Occup Med     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1988-01-21     Completed Date:  1988-01-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7502807     Medline TA:  J Occup Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  877-83     Citation Subset:  IM    
Centers for Disease Control, National Institute for Occupational Safety and Health, Cincinnati, OH 45226.
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MeSH Terms
Acetone / pharmacokinetics
Body Burden
Breath Tests
Butanones / pharmacokinetics
Environmental Monitoring
Solvents / blood,  pharmacokinetics*
Reg. No./Substance:
0/Butanones; 0/Solvents; 67-64-1/Acetone; 78-93-3/methylethyl ketone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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