| Body mass index, fasting plasma glucose levels, and C-peptide levels as predictors of the future insulin use in Japanese type 2 diabetic patients. | |
| | |
MedLine Citation:
|
PMID: 20032566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Insulin therapy represents the most effective and reliable means of achieving satisfactory glycemic control. However, few studies have evaluated the predictors of future insulin use. The purpose of this study was to investigate the predictors of future insulin use in type 2 diabetic patients. In this study, we conducted a chart review of 158 Japanese type 2 diabetic patients admitted to our hospital for stringent glycemic control. Of the 158 subjects, 92 satisfied the inclusion criteria for this study. We assessed the associations between baseline BMI, fasting plasma glucose levels (FPG) and serum and urinary C-peptide levels (sCPR and uCPR), and insulin usage at 6 months after discharge. We also computed the areas under the curve (AUCs) in receiver operator characteristic (ROC) curves for each predictor to predict the future insulin use. After adjustment for gender, age, and BMI, the multivariable odds ratios (ORs) for future insulin use in the highest tertile as compared with lowest tertile were 0.12 for BMI (95% confidence interval (CI), 0.03-0.52), 17.0 for FPG (95% CI, 3.27-88.7), 0.12 for sCPR (95% CI, 0.02-0.71), and 0.03 for uCPR (95% CI, 0.00-0.24). Prediction analyses showed that the AUCs for BMI, FPG, sCPR, and uCPR were 0.73, 0.76, 0.74, and 0.78, respectively, which suggests that the predictive abilities of these predictors do not differ substantially. In conclusion, this study suggests that BMI, FPG, sCPR, and uCPR are strong predictors of the future insulin use in type 2 diabetic patients. |
| | |
Authors:
|
Atsushi Goto; Maki Takaichi; Miyako Kishimoto; Yoshihiko Takahashi; Hiroshi Kajio; Takuro Shimbo; Mitsuhik Noda |
Related Documents
:
|
16651496 - Prevalence of diabetes and impaired fasting glucose levels among us adolescents: nation... 16186056 - Smoking and development of type 2 diabetes in patients with decreased functional capacity. 20089496 - Presence of gallstones or kidney stones and risk of type 2 diabetes. 11724416 - Incidence of type i diabetes mellitus in children and young adults in the province of u... 22414336 - Preferences of people with diabetes for diabetic retinopathy screening: a discrete choi... 7972266 - Free fatty acid profiles in the non-obese diabetic (nod) mouse: basal serum levels and ... |
Publication Detail:
|
Type: Journal Article Date: 2009-12-23 |
Journal Detail:
|
Title: Endocrine journal Volume: 57 ISSN: 1348-4540 ISO Abbreviation: Endocr. J. Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-04-09 Completed Date: 2010-06-28 Revised Date: 2011-06-16 |
Medline Journal Info:
|
Nlm Unique ID: 9313485 Medline TA: Endocr J Country: Japan |
Other Details:
|
Languages: eng Pagination: 237-44 Citation Subset: IM |
Affiliation:
|
Department of Diabetes and Metabolic Medicine, International Medical Center of Japan, Toyama Hospital, Tokyo, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Area Under Curve Asian Continental Ancestry Group Blood Glucose / analysis*, metabolism Body Mass Index* C-Peptide / blood*, urine Diabetes Mellitus, Type 2 / drug therapy* Fasting Female Humans Insulin / blood*, therapeutic use* Japan Male Middle Aged Predictive Value of Tests |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/C-Peptide; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Lipid profiles in the untreated patients with Hashimoto thyroiditis and the effects of thyroxine tre...
Next Document: A case of ectopic adrenocorticotropic hormone-producing pancreatic neuroendocrine tumor with multipl...