| Body Mass Index, Exercise Capacity, and Mortality Risk in Male Veterans With Hypertension. | |
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MedLine Citation:
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PMID: 22237157 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BackgroundOverweight and obesity are associated with increased risk of chronic diseases and mortality. Exercise capacity is inversely associated with mortality risk. However, little is known on the interaction between fitness, fatness, and mortality risk in hypertensive individuals. Thus, we assessed the interaction between exercise capacity, fatness, and all-cause mortality in hypertensive males.MethodsA graded exercise test was performed in 4,183 hypertensive veterans (mean age ± s.d.; 63.3 ± 10.5 years) at the Veterans Affairs Medical Center, Washington, DC. We defined three body weight categories based on body mass index (BMI): normal weight (BMI <25); overweight (BMI 25-29.9); and obese (BMI ≥30); and three fitness categories based on peak metabolic equivalents (METs) achieved: low-fit (≤5 METs); moderate-fit (5.1-7.5 MET); and high-fit (>7.5 METs).ResultsDuring a median follow-up period of 7.2 years, there were 1,000 deaths. The association between exercise capacity and mortality risk was strong, inverse, and graded. For each 1-MET increase in exercise capacity the adjusted risk was 20% for normal weight, 12% for overweight, and 25% for obese (P < 0.001). When compared to normal weight but unfit individuals, mortality risks were 60% lower in the overweight/high-fit and 78% lower in the obese/high-fit individuals (P < 0.001).ConclusionsIncreased exercise capacity is associated with lower mortality risk in hypertensive males regardless of BMI. The risk for overweight and obese but fit individuals was significantly lower when compared to normal weight but unfit. These findings suggest that in older hypertensive men, it may be healthier to be fit regardless of standard BMI category than unfit and normal weight.American Journal of Hypertension (2011). doi:10.1038/ajh.2011.242. |
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Authors:
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Charles Faselis; Michael Doumas; Demosthenes Panagiotakos; Raya Kheirbek; Lauren Korshak; Athanasios Manolis; Andreas Pittaras; Costas Tsioufis; Vasilios Papademetriou; Ross Fletcher; Peter Kokkinos |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-12 |
Journal Detail:
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Title: American journal of hypertension Volume: - ISSN: 1941-7225 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1] Department of Medicine, Veterans Affairs Medical Center, Washington, DC, USA [2] Department of Medicine, George Washington University School of Medicine, Washington, DC, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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