Document Detail


Bmp2 signaling regulates the hepatic versus pancreatic fate decision.
MedLine Citation:
PMID:  19000838     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Explant culture data have suggested that the liver and pancreas originate from common progenitors. We used single-cell-lineage tracing in zebrafish to investigate this question in vivo as well as to analyze the hepatic versus pancreatic fate decision. At early somite stages, endodermal cells located at least two cells away from the midline can give rise to both liver and pancreas. In contrast, endodermal cells closer to the midline give rise to pancreas and intestine, but not liver. Loss- and gain-of-function analyses show that Bmp2b, expressed in the lateral plate mesoderm, signals through Alk8 to induce endodermal cells to become liver. When Bmp2b was overexpressed, medially located endodermal cells, fated to become pancreas and intestine, contributed to the liver. These data provide in vivo evidence for the existence of bipotential hepatopancreatic progenitors and indicate that their fate is regulated by the medio-lateral patterning of the endodermal sheet, a process controlled by Bmp2b.
Authors:
Won-Suk Chung; Chong Hyun Shin; Didier Y R Stainier
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental cell     Volume:  15     ISSN:  1878-1551     ISO Abbreviation:  Dev. Cell     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-12     Completed Date:  2009-02-11     Revised Date:  2011-09-26    
Medline Journal Info:
Nlm Unique ID:  101120028     Medline TA:  Dev Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  738-48     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone Morphogenetic Protein 2 / metabolism*
Embryo, Nonmammalian / metabolism
Liver / embryology*,  metabolism
Organogenesis
Pancreas / embryology*,  metabolism
Signal Transduction
Zebrafish / embryology*,  metabolism
Grant Support
ID/Acronym/Agency:
DK60322/DK/NIDDK NIH HHS; F32DK068891/DK/NIDDK NIH HHS; R01 DK060322-07/DK/NIDDK NIH HHS; R01 DK060322-08/DK/NIDDK NIH HHS; R01 DK060322-09/DK/NIDDK NIH HHS; R01 DK075032-02/DK/NIDDK NIH HHS; R01 DK075032-03/DK/NIDDK NIH HHS; R01 DK075032-03S1/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Bone Morphogenetic Protein 2
Comments/Corrections

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