| Bmp2 is required for cephalic neural tube closure in the mouse. | |
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MedLine Citation:
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PMID: 19097048 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BMPs have been shown to play a role in neural tube development particularly as dorsalizing factors. To explore the possibility that BMP2 could play a role in the developing neural tube (NT) beyond the lethality of Bmp2 null embryos, we created Bmp2 chimeras from Bmp2 null ES cells and WT blastocysts. Analysis of Bmp2 chimeras reveals NT defects at day 9.5 (E9.5). We found that exclusion of Bmp2 null ES cells from the dorsal NT did not always prevent defects. For further comparison, we used a Bmp2 mutant line in a mixed background. Phenotypes observed were similar to chimeras including open NT defects, postneurulation defects, and abnormal neural ectoderm in heterozygous and homozygous null embryos demonstrating a pattern of dose-dependent signaling. Our data exposes BMP2 as a unique player in the developing NT for dorsal patterning and identity, and normal cephalic neural tube closure in a dose-dependent manner. |
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Authors:
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Trisha Castranio; Yuji Mishina |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural |
Journal Detail:
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Title: Developmental dynamics : an official publication of the American Association of Anatomists Volume: 238 ISSN: 1058-8388 ISO Abbreviation: Dev. Dyn. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-05 Completed Date: 2009-03-23 Revised Date: 2012-03-07 |
Medline Journal Info:
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Nlm Unique ID: 9201927 Medline TA: Dev Dyn Country: United States |
Other Details:
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Languages: eng Pagination: 110-22 Citation Subset: IM |
Affiliation:
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Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. castran1@niehs.nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / physiology Benzothiazoles / metabolism Body Patterning* Bone Morphogenetic Protein 2 / genetics, metabolism* Chimera / anatomy & histology, physiology Female In Situ Hybridization Mice Mice, Knockout Neural Tube / anatomy & histology, physiology* Paired Box Transcription Factors / genetics, metabolism Phenotype Pregnancy Signal Transduction / physiology Toluene / analogs & derivatives, metabolism Tumor Suppressor Protein p53 / genetics, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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Z99 ES999999/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Benzothiazoles; 0/Bone Morphogenetic Protein 2; 0/Paired Box Transcription Factors; 0/Tumor Suppressor Protein p53; 0/pifithrin; 108-88-3/Toluene; 138016-91-8/Pax3 protein, mouse |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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