Document Detail


Bmf is upregulated by PS-341-mediated cell death of glioma cells through JNK phosphorylation.
MedLine Citation:
PMID:  19267218     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Malignant glioma is resistant to the induction of apoptosis, resulting in a subsequent failure of chemotherapy in clinical treatment strategies. Downregulation of bcl-2 and bcl-xl expression in glioblastoma cells can induce apoptosis. BH3-only proteins, which include Bmf, are essential initiators of stress-induced cell death and apoptosis. Whether PS-341 regulates expression of BH3-only proteins in glioblastoma cells during the procedure of apoptosis is unclear. This study was designed to investigate the effects of PS-341 on glioma cell death and its possible signaling pathway. Our results demonstrate that Bmf is upregulated by PS-341 in A172 and T98G cells, and Bmf has a crucial role in PS-341-mediated cell death. In addition, we found that expression of Bmf is regulated by JNK phosphorylation.
Authors:
Zheng Tianhu; Zhao Shiguang; Liu Xinghan
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Publication Detail:
Type:  Journal Article     Date:  2009-03-07
Journal Detail:
Title:  Molecular biology reports     Volume:  37     ISSN:  1573-4978     ISO Abbreviation:  Mol. Biol. Rep.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-05-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0403234     Medline TA:  Mol Biol Rep     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1211-9     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Harbin Medical University, Harbin, China.
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MeSH Terms
Descriptor/Qualifier:
Adaptor Proteins, Signal Transducing / metabolism*
Analysis of Variance
Antineoplastic Agents / pharmacology*
Apoptosis / drug effects*
Blotting, Western
Boronic Acids / pharmacology*
Cell Line, Tumor
DNA Fragmentation
Flow Cytometry
Gene Expression Regulation, Neoplastic / drug effects*
Glioma / metabolism*
Humans
MAP Kinase Kinase 4 / metabolism
Phosphorylation
Pyrazines / pharmacology*
RNA, Small Interfering / genetics
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction / drug effects*
Tetrazolium Salts
Thiazoles
Chemical
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/Antineoplastic Agents; 0/BMF protein, human; 0/Boronic Acids; 0/Pyrazines; 0/RNA, Small Interfering; 0/Tetrazolium Salts; 0/Thiazoles; 0/bortezomib; 298-93-1/thiazolyl blue; EC 2.7.12.2/MAP Kinase Kinase 4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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