Document Detail

Bmf is upregulated by PS-341-mediated cell death of glioma cells through JNK phosphorylation.
MedLine Citation:
PMID:  19267218     Owner:  NLM     Status:  MEDLINE    
Malignant glioma is resistant to the induction of apoptosis, resulting in a subsequent failure of chemotherapy in clinical treatment strategies. Downregulation of bcl-2 and bcl-xl expression in glioblastoma cells can induce apoptosis. BH3-only proteins, which include Bmf, are essential initiators of stress-induced cell death and apoptosis. Whether PS-341 regulates expression of BH3-only proteins in glioblastoma cells during the procedure of apoptosis is unclear. This study was designed to investigate the effects of PS-341 on glioma cell death and its possible signaling pathway. Our results demonstrate that Bmf is upregulated by PS-341 in A172 and T98G cells, and Bmf has a crucial role in PS-341-mediated cell death. In addition, we found that expression of Bmf is regulated by JNK phosphorylation.
Zheng Tianhu; Zhao Shiguang; Liu Xinghan
Related Documents :
15902208 - An inhibitor of bcl-2 family proteins induces regression of solid tumours.
23622308 - Inflammatory, vascular, and infectious myelopathies in children.
16162358 - Nocodazole, a microtubule de-polymerising agent, induces apoptosis of chronic lymphocyt...
11687888 - Derivatives of monoglycerides as apoptotic agents in t-cells.
20472598 - Il-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-tnf ...
20375608 - Role of nadph oxidase in formation and function of multinucleated giant cells.
Publication Detail:
Type:  Journal Article     Date:  2009-03-07
Journal Detail:
Title:  Molecular biology reports     Volume:  37     ISSN:  1573-4978     ISO Abbreviation:  Mol. Biol. Rep.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-05-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0403234     Medline TA:  Mol Biol Rep     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1211-9     Citation Subset:  IM    
Department of Biochemistry, Harbin Medical University, Harbin, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adaptor Proteins, Signal Transducing / metabolism*
Analysis of Variance
Antineoplastic Agents / pharmacology*
Apoptosis / drug effects*
Blotting, Western
Boronic Acids / pharmacology*
Cell Line, Tumor
DNA Fragmentation
Flow Cytometry
Gene Expression Regulation, Neoplastic / drug effects*
Glioma / metabolism*
MAP Kinase Kinase 4 / metabolism
Pyrazines / pharmacology*
RNA, Small Interfering / genetics
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction / drug effects*
Tetrazolium Salts
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/Antineoplastic Agents; 0/BMF protein, human; 0/Boronic Acids; 0/Pyrazines; 0/RNA, Small Interfering; 0/Tetrazolium Salts; 0/Thiazoles; 0/bortezomib; 298-93-1/thiazolyl blue; EC Kinase Kinase 4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Type II Gaucher disease manifesting as haemophagocytic lymphohistiocytosis.
Next Document:  The concept of disease-vague, complex, or just indefinable?