Document Detail


BmK I, an alpha-like scorpion neurotoxin, specifically modulates isolated rat cardiac mechanical and electrical activity.
MedLine Citation:
PMID:  14566399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, cardiotonic and cardiotoxic effects of Buthus martensi Karsch (BmK) I, a modulator of voltage-gated sodium channels, were investigated on the isolated rat hearts. The results showed that BmK I evoked complex effects characterized by a change in both cardiac mechanical and electrical activity. Langendorff perfusion showed that: (1) maximal left ventricular developed pressure (LVDP(max)) and dp/dt(max) were markedly increased by BmK I (0.5-10 micromol/L) in a dose-dependent manner (n=6, P<0.05), positive chronotropic effects were also induced by BmK I (n=6, P<0.05); (2) negative inotropic action and bradycardia could be elicited at a larger dose of BmK I (20 micromol/L); (3) the coronary flow varied inversely with the positive inotropic effects, coronary flow reduced during positive inotropic effects from 14.5 to 8.6 ml/min after administration of 500 nmol/L BmK I (n=6, P<0.05). In addition, tachycardia and complex cardiac arrhythmias were induced by BmK I (0.5-10 micromol/L). The modulating of BmK I on the heart mechanical, electrical activity could be partially recovered after washing. As propranolol was applied to block the release of catecholamines before administration of BmK I, suggesting that the changes in cardiac mechanical and electrical activity induced by BmK I might not due to catecholamine release from the nerve terminal and subsequent stimulation of the beta-adrenoceptor but attributable to the modulation of BmK I on cardiac voltage-gated sodium channels.
Authors:
Hai-Ying Sun; Hai-Feng Zhu; Yong-Hua Ji
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Sheng li xue bao : [Acta physiologica Sinica]     Volume:  55     ISSN:  0371-0874     ISO Abbreviation:  Sheng Li Xue Bao     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-20     Completed Date:  2004-07-22     Revised Date:  2011-07-22    
Medline Journal Info:
Nlm Unique ID:  20730130R     Medline TA:  Sheng Li Xue Bao     Country:  China    
Other Details:
Languages:  eng     Pagination:  530-4     Citation Subset:  IM    
Affiliation:
Institute of Physiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / drug effects*
Animals
Electrophysiology
Insect Proteins
Male
Myocardial Contraction / drug effects*
Neurotoxins / pharmacology*
Patch-Clamp Techniques
Rats
Rats, Sprague-Dawley
Scorpion Venoms / pharmacology*
Sodium Channel Blockers / pharmacology*
Sodium Channels / drug effects
Chemical
Reg. No./Substance:
0/BmK M1 neurotoxin; 0/Insect Proteins; 0/Neurotoxins; 0/Scorpion Venoms; 0/Sodium Channel Blockers; 0/Sodium Channels; 0/sodium channel protein type 5 subunit alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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