| BlyS: a potential hallmark of multiple myeloma. | |
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MedLine Citation:
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PMID: 23276925 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Multiple myeloma (MM) is a plasma cell dyscrasia characterized by bone lesions and production of a paraprotein. B-lymphocyte stimulator (BLyS) and its receptor (BAFFR) were highly expressed on peripheral blood and bone marrow B cells in MM patients as compared to those with monoclonal gammopathy of unknown significance (MGUS) and healthy donors. Serum BLyS levels in MM patients were significantly higher than those in MGUS patients and healthy controls. BLyS expression was increased in bone marrow specimens from MM patients as ascertained by immunofluorescence. Furthermore, BLyS, together with IL-2 and IL-6, significantly promoted MM cell proliferation and BLyS receptor expression compared with that in the control group. Treatment with bortezomib, a therapeutic proteasome inhibitor induced apoptosis and repressed the proliferation of RPMI8226 and U266 cells through inhibition of NF-?B p65 and I?Ba. These findings suggest that BLyS is involved in the immunopathogenesis of MM and may prove to be a hallmark of MM. |
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Authors:
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Ping Wang; Liu Qian; Xiang Liang Yuan; Chao Ying Hu; Lian Sheng Wang; Qiu Yu Huang; Ping Miao; Qiwen Yu; Yan Hui Ma; Ji Ying Zhang; Xue Hua Chen; Bing Ya Liu; Li Song Shen; Dong Qing Zhang |
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Publication Detail:
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Type: Journal Article Date: 2013-01-01 |
Journal Detail:
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Title: Frontiers in bioscience : a journal and virtual library Volume: 18 ISSN: 1093-4715 ISO Abbreviation: Front. Biosci. Publication Date: 2013 |
Date Detail:
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Created Date: 2013-01-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709506 Medline TA: Front Biosci Country: United States |
Other Details:
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Languages: eng Pagination: 324-31 Citation Subset: IM |
Affiliation:
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Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai 200025, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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