Document Detail

Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men.
MedLine Citation:
PMID:  1325348     Owner:  NLM     Status:  MEDLINE    
The effect of chronic administration of phosphatidylserine derived from brain cortex on the neuroendocrine responses to physical stress has been examined in a placebo-controlled study in 9 healthy men. Phosphatidylserine 800 mg/d for 10 days significantly blunted the ACTH and cortisol responses to physical exercise (P = 0.003 and P = 0.03, respectively), without affecting the rise in plasma GH and PRL. Physical exercise significantly increased the plasma lactate concentration both after placebo and phosphatidylserine. The results suggest that chronic oral administration of phosphatidylserine may counteract stress-induced activation of the hypothalamo-pituitary-adrenal axis in man.
P Monteleone; M Maj; L Beinat; M Natale; D Kemali
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  42     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1992  
Date Detail:
Created Date:  1992-10-06     Completed Date:  1992-10-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  385-8     Citation Subset:  IM    
Institute of Psychiatry, First Medical School, University of Naples, Italy.
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MeSH Terms
Administration, Oral
Adrenocorticotropic Hormone / secretion
Hydrocortisone / secretion
Hypothalamo-Hypophyseal System / drug effects*,  physiology
Phosphatidylserines / administration & dosage*,  pharmacology
Pituitary-Adrenal System / drug effects*,  physiology
Stress, Physiological / physiopathology*
Time Factors
Reg. No./Substance:
0/Phosphatidylserines; 50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone

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