Document Detail


Blunted neuronal calcium response to hypoxia in naked mole-rat hippocampus.
MedLine Citation:
PMID:  22363676     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Naked mole-rats are highly social and strictly subterranean rodents that live in large communal colonies in sealed and chronically oxygen-depleted burrows. Brain slices from naked mole-rats show extreme tolerance to hypoxia compared to slices from other mammals, as indicated by maintenance of synaptic transmission under more hypoxic conditions and three fold longer latency to anoxic depolarization. A key factor in determining whether or not the cellular response to hypoxia is reversible or leads to cell death may be the elevation of intracellular calcium concentration. In the present study, we used fluorescent imaging techniques to measure relative intracellular calcium changes in CA1 pyramidal cells of hippocampal slices during hypoxia. We found that calcium accumulation during hypoxia was significantly and substantially attenuated in slices from naked mole-rats compared to slices from laboratory mice. This was the case for both neonatal (postnatal day 6) and older (postnatal day 20) age groups. Furthermore, while both species demonstrated more calcium accumulation at older ages, the older naked mole-rats showed a smaller calcium accumulation response than even the younger mice. A blunted intracellular calcium response to hypoxia may contribute to the extreme hypoxia tolerance of naked mole-rat neurons. The results are discussed in terms of a general hypothesis that a very prolonged or arrested developmental process may allow adult naked mole-rat brain to retain the hypoxia tolerance normally only seen in neonatal mammals.
Authors:
Bethany L Peterson; John Larson; Rochelle Buffenstein; Thomas J Park; Christopher P Fall
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-02-21
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-24     Completed Date:  2012-06-29     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e31568     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, United States of America.
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MeSH Terms
Descriptor/Qualifier:
Aging / metabolism
Animals
Anoxia / pathology*
Calcium / metabolism*
Female
Hippocampus / drug effects,  metabolism*,  pathology*
Imaging, Three-Dimensional
Mice
Mice, Inbred C57BL
Mole Rats
Neurons / drug effects,  metabolism*,  pathology
Potassium / pharmacology
Solutions
Grant Support
ID/Acronym/Agency:
MH-085973/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Solutions; 7440-09-7/Potassium; 7440-70-2/Calcium
Comments/Corrections

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