Document Detail

Blunted heart rate response to upright tilt in people with Down syndrome.
MedLine Citation:
PMID:  15827937     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine whether heart rate and blood pressure responses to upright tilt would be lower in subjects with Down syndrome (DS) than in control subjects with no disabilities. DESIGN: Comparative study. SETTING: University research laboratory. PARTICIPANTS: Nineteen people with DS (mean age, 25.1+/-7.3 y) and 17 control subjects without disabilities (mean age, 28.4+/-5.6 y). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Heart rate and blood pressure recordings were obtained at rest and during a 2-minute period of passive head up tilt to 80 degrees . RESULTS: Heart rate and blood pressure increased significantly during the first 30 seconds of upright tilt in both groups ( P <.05) and then stabilized for the remainder of the test. The initial heart rate response to head up tilt (first 30s) was significantly higher in controls compared with subjects with DS ( P <.05), whereas the blood pressure response did not differ between groups ( P >.05). Controlling for heart rate reserve showed a blunted heart rate response through the tilt period in subjects with DS. CONCLUSIONS: These data show a blunted heart rate response to upright tilt in people with DS, despite similar changes in blood pressure, consistent with reduced sympathoexcitation and possibly altered baroreceptor function in these people with DS.
Bo Fernhall; Arturo Figueroa; Scott Collier; Tracy Baynard; Ifigenia Giannopoulou; Styliani Goulopoulou
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of physical medicine and rehabilitation     Volume:  86     ISSN:  0003-9993     ISO Abbreviation:  Arch Phys Med Rehabil     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-13     Completed Date:  2005-05-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985158R     Medline TA:  Arch Phys Med Rehabil     Country:  United States    
Other Details:
Languages:  eng     Pagination:  813-8     Citation Subset:  AIM; IM    
Exercise Science Department, Syracuse University, NY, USA.
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MeSH Terms
Blood Pressure / physiology
Down Syndrome / physiopathology*
Heart Rate / physiology*
Tilt-Table Test*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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