| Blunted febrile response to intravenous endotoxin in starved rats. | |
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MedLine Citation:
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PMID: 2793726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of fasting on the febrile responses to intravenous injection of bacterial lipopolysaccharide (LPS; endotoxin) of Escherichia coli were investigated in rats. Ad libitum-fed rats (C) produced a biphasic fever with an increase in the temperature difference between brown adipose tissue and colon and shivering activity (SA). Measurement by a direct calorimeter showed no particular changes in heat loss. Rats starved for 4 days (F4) responded to intravenous LPS with a monophasic fever accompanied by an increase in SA only. However the maximal rise in colonic temperature (Tco) did not differ from C rats. Subsequent 2-day fasting reduced SA and the maximal fever height. Endogenous pyrogen (EP) injected intravenously produced a prompt rise in Tco followed by prolonged hyperthermia in C rats. In the F4 rats, there was no such sustained rise in Tco as a result of intravenous EP. The response in Tco to intravenous prostaglandin E2 (PGE2) was the same in fed and starved rats. The administration of LPS, EP, and PGE2 into the lateral ventricle evoked a similar extent of hyperthermia in C and F4 rats. Because the second phase of fever has been shown to occur after pyrogens are translated into a febrile stimulus within the blood-brain barrier, it is assumed that the functional changes of the blood-brain barrier such as in the permeability of pyrogens or in the sensitivity of pyrogen receptors resulted in the absence of the second phase of fever in starved rats. |
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Authors:
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O Shido; T Nagasaka; T Watanabe |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 67 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1989 Sep |
Date Detail:
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Created Date: 1989-11-21 Completed Date: 1989-11-21 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 963-9 Citation Subset: IM |
Affiliation:
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Department of Physiology, School of Medicine, Kanazawa University, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Regulation / drug effects Dinoprostone / pharmacology Endotoxins / administration & dosage, toxicity* Fever / chemically induced*, physiopathology Injections, Intravenous Interleukin-1 / pharmacology Lipopolysaccharides / administration & dosage, toxicity Male Pyrogens / pharmacology Rats Rats, Inbred Strains Starvation |
| Chemical | |
Reg. No./Substance:
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0/Endotoxins; 0/Interleukin-1; 0/Lipopolysaccharides; 0/Pyrogens; 0/leukocyte endogenous mediator; 363-24-6/Dinoprostone |
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