Document Detail


Blunted behavioral and c Fos responses to acidic fumes in the African naked mole-rat.
MedLine Citation:
PMID:  23028761     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acidosis in the skin triggers activation of pain pathways and behaviors indicative of pain in vertebrates. The exception is the naked mole-rat, the only known vertebrate to show physiological and behavioral insensitivity to acid pain in the skin. The goal of the present study was to determine behavioral and physiological responses of this species to airborne acidic fumes, which would be expected to affect the trigeminal pain pathway in other species. Behaviorally, naked mole-rats did not avoid fumes from moderately high concentrations of acetic acid (10 and 20%), and c Fos labeling showed no increase in activity in the trigeminal nuclei and nucleus tractus solitarius. In contrast, these concentrations triggered behavioral aversion and increased Fos activity in other laboratory rodents. For a very high concentration of acetic acid (50%), naked mole-rats showed significant avoidance behavior and increased Fos labeling in the nucleus tractus solitarius caudal region, which receives vagal chemosensory information. However, there was no increase in trigeminal labeling, and in fact, activity significantly decreased. This pattern is opposite of that associated with another irritant, ammonia fumes, which elicited an increase in trigeminal but not nucleus tractus solitarius Fos labeling, and no behavioral avoidance. Behavioral avoidance of acidic fumes, but no increased labeling in the trigeminal pain nucleus is consistent with the notion of adaptations to blunt acid pain, which would be advantageous for naked mole-rats as they normally live under chronically high levels of acidosis-inducing CO(2).
Authors:
Pamela Colleen LaVinka; Thomas J Park
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-09-17
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-02     Completed Date:  2013-02-26     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e45060     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences and the Laboratory of Integrative Neuroscience, University of Illinois at Chicago, Chicago, Illinois, USA.
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MeSH Terms
Descriptor/Qualifier:
Acetic Acid / pharmacology*
Africa
Ammonia / pharmacology
Animals
Avoidance Learning / drug effects
Behavior, Animal / drug effects*
Cell Count
Irritants / pharmacology*
Mice
Mice, Inbred C57BL
Mole Rats
Proto-Oncogene Proteins c-fos / metabolism*
Rats
Rats, Long-Evans
Rats, Sprague-Dawley
Solitary Nucleus / cytology,  drug effects,  metabolism
Staining and Labeling
Trigeminal Nuclei / cytology,  drug effects,  metabolism
Chemical
Reg. No./Substance:
0/Irritants; 0/Proto-Oncogene Proteins c-fos; 64-19-7/Acetic Acid; 7664-41-7/Ammonia
Comments/Corrections

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