| Blunted TSH response to TRH and seizure duration in ECT. | |
| | |
MedLine Citation:
|
PMID: 10066009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The relationship between the thyrotropin (TSH) response to thyrotropin-releasing hormone (TRH) and the duration of seizures induced by electroconvulsive therapy (ECT) in depressed patients was investigated. In a balanced-order cross-over design, 16 depressed women were given 0.4 mg TRH or placebo intravenously, 20 min before ECT in the first two sessions. In the third ECT session TRH was given just prior to ECT. Thyrotropin (TSH) levels at various sampling times, as well as the duration of seizures, were measured. There was a significant inverse correlation between plasma TSH concentrations 20 min after TRH administration (deltaTSH) and seizure duration. Furthermore, when patients were categorized according to their TSH response to TRH, the group with blunted responses (deltaTSH <6 microIU/ mL, n = 7) had a longer seizure time during ECT than the group with non-blunted responses (deltaTSH > 6 microIU/mL, n = 9). Finally, the seizure duration in the group with blunted TSH responses was reduced significantly when TRH was co-administered, while it remained unchanged in the group with non-blunted TSH responses. It is concluded that a blunted TSH response to TRH might indicate a seizure susceptibility as measured by the duration of seizures induced by ECT. The fact that TRH pre-administration had a reducing effect suggests that this substance might be involved in the pathophysiology of ECT-induced seizures. |
| | |
Authors:
|
Y G Papakostas; M Markianos; A Pehlivanidis; I M Zervas; G N Papadimitriou; C Stefanis |
Related Documents
:
|
6441729 - Beta-casomorphin inhibits thyrotropin secretion in rats. 17380819 - Hypothyroidism. 98209 - Trh-like immunoreactivity in urine, serum and extrahypothalamic brain: non-identity wit... 9358829 - Thyroid dysfunction in the elderly. 7238449 - Pharmacological studies of the involvement of hypothalamic prostaglandins in the regula... 6802529 - Clomiphene citrate does not modify the exaggerated thyrotrophin response to thyrotrophi... 15225239 - Interleukin 1 beta and tumor necrosis factor levels in stored platelet concentrates and... 8289479 - Estimation of effective and total erythropoiesis in myelodysplasia using serum transfer... 6790199 - Reduction of plasma high-density lipoprotein cholesterol and increase of postheparin pl... |
Publication Detail:
|
Type: Clinical Trial; Journal Article |
Journal Detail:
|
Title: Acta psychiatrica Scandinavica Volume: 99 ISSN: 0001-690X ISO Abbreviation: Acta Psychiatr Scand Publication Date: 1999 Jan |
Date Detail:
|
Created Date: 1999-06-02 Completed Date: 1999-06-02 Revised Date: 2005-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0370364 Medline TA: Acta Psychiatr Scand Country: DENMARK |
Other Details:
|
Languages: eng Pagination: 68-72 Citation Subset: IM |
Affiliation:
|
Psychiatry Department and University Mental Health, Research Institute, Athens University, Medical School, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Bipolar Disorder / diagnosis Cross-Over Studies Electroconvulsive Therapy / adverse effects* Female Humans Middle Aged Psychiatric Status Rating Scales Seizures / etiology* Thyrotropin / blood, metabolism* Thyrotropin-Releasing Hormone / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
24305-27-9/Thyrotropin-Releasing Hormone; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Long-term outcome of pharmacological and psychological treatment for panic disorder with agoraphobia...
Next Document: Changes in public attitudes towards mental illness in the Athens area (1979/1980-1994).