| Blue-yellow opponency in primate S cone photoreceptors. | |
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MedLine Citation:
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PMID: 20071519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The neural coding of human color vision begins in the retina. The outputs of long (L)-, middle (M)-, and short (S)-wavelength-sensitive cone photoreceptors combine antagonistically to produce "red-green" and "blue-yellow" spectrally opponent signals (Hering, 1878; Hurvich and Jameson, 1957). Spectral opponency is well established in primate retinal ganglion cells (Reid and Shapley, 1992; Dacey and Lee, 1994; Dacey et al., 1996), but the retinal circuitry creating the opponency remains uncertain. Here we find, from whole-cell recordings of photoreceptors in macaque monkey, that "blue-yellow" opponency is already present in the center-surround receptive fields of S cones. The inward current evoked by blue light derives from phototransduction within the outer segment of the S cone. The outward current evoked by yellow light is caused by feedback from horizontal cells that are driven by surrounding L and M cones. Stimulation of the surround modulates calcium conductance in the center S cone. |
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Authors:
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Orin S Packer; Jan Verweij; Peter H Li; Julie L Schnapf; Dennis M Dacey |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 30 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-14 Completed Date: 2010-02-01 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 568-72 Citation Subset: IM |
Affiliation:
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Department of Biological Structure and the National Primate Research Center, University of Washington, Seattle, Washington 98195, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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6-Cyano-7-nitroquinoxaline-2,3-dione
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pharmacology Animals Biofeedback, Psychology / physiology Biophysics Calcium / metabolism Color* Color Perception / physiology* Excitatory Amino Acid Antagonists / pharmacology Light Membrane Potentials / drug effects, physiology Neural Inhibition / drug effects Patch-Clamp Techniques / methods Photic Stimulation / methods Potassium Channel Blockers / pharmacology Primates / anatomy & histology Retina / cytology* Retinal Cone Photoreceptor Cells / classification, physiology* Tetraethylammonium / pharmacology Visual Fields / physiology |
| Grant Support | |
ID/Acronym/Agency:
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EY01730/EY/NEI NIH HHS; EY02162/EY/NEI NIH HHS; EY06678/EY/NEI NIH HHS; EY07642/EY/NEI NIH HHS; P30 EY001730-34/EY/NEI NIH HHS; P51 RR000166-426610/RR/NCRR NIH HHS; R01 EY006678-24/EY/NEI NIH HHS; RR00166/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Excitatory Amino Acid Antagonists; 0/Potassium Channel Blockers; 115066-14-3/6-Cyano-7-nitroquinoxaline-2,3-dione; 66-40-0/Tetraethylammonium; 7440-70-2/Calcium |
| Comments/Corrections | |
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