Document Detail

Blue dye, green heart.
MedLine Citation:
PMID:  18703358     Owner:  NLM     Status:  MEDLINE    
Methylene blue has been used for the rapid reversal of circulatory shock refractory to fluid administration, inotropic agents, and vasoconstrictors. Its clinical side effects have been well described. We report an interesting autopsy observation in patients who received methylene blue as adjunct therapy for septic shock. The exposed surface of cardiac myocardium on both fresh and fixed states rapidly turned green. In the presence of molecular oxygen, the colorless metabolite leukomethylene blue is readily oxidized to methylene blue, thus explaining the visible color change of the myocardium.
Carmela D Tan; E Rene Rodriguez
Related Documents :
17079038 - Acute reversible cardiomyopathy with cardiogenic shock in a patient with addisonian cri...
6734228 - Two-dimensional echocardiographic demonstration of acute myocardial depression in septi...
3177678 - Influence of shock strength and timing on induction of ventricular arrhythmias in dogs.
10618308 - Staphylococcal alpha-toxin provokes coronary vasoconstriction and loss in myocardial co...
8073948 - Therapeutic regulation of the complement system in acute injury states.
17925618 - Estimating the incidence of the acute coronary syndrome: data from a danish cohort of 1...
Publication Detail:
Type:  Journal Article     Date:  2008-08-13
Journal Detail:
Title:  Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology     Volume:  19     ISSN:  1879-1336     ISO Abbreviation:  Cardiovasc. Pathol.     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-02-09     Completed Date:  2010-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9212060     Medline TA:  Cardiovasc Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  125-6     Citation Subset:  IM    
Department of Anatomic Pathology, Cleveland Clinic, 9500 Euclid Avenue/L25, Cleveland, OH 44195, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cardiotonic Agents / administration & dosage*,  chemistry
Enzyme Inhibitors / administration & dosage*,  chemistry
Methylene Blue / administration & dosage*,  chemistry
Myocardium / chemistry,  metabolism,  pathology*
Shock, Septic / drug therapy*,  pathology,  physiopathology
Staining and Labeling
Reg. No./Substance:
0/Cardiotonic Agents; 0/Enzyme Inhibitors; 61-73-4/Methylene Blue

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Suture knot embolism-a rare complication of percutaneous arterial closure device.
Next Document:  Mitral repair with the Evalve MitraClip device: histopathologic findings in the porcine model.