| Blue dye, green heart. | |
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MedLine Citation:
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PMID: 18703358 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Methylene blue has been used for the rapid reversal of circulatory shock refractory to fluid administration, inotropic agents, and vasoconstrictors. Its clinical side effects have been well described. We report an interesting autopsy observation in patients who received methylene blue as adjunct therapy for septic shock. The exposed surface of cardiac myocardium on both fresh and fixed states rapidly turned green. In the presence of molecular oxygen, the colorless metabolite leukomethylene blue is readily oxidized to methylene blue, thus explaining the visible color change of the myocardium. |
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Authors:
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Carmela D Tan; E Rene Rodriguez |
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Publication Detail:
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Type: Journal Article Date: 2008-08-13 |
Journal Detail:
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Title: Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology Volume: 19 ISSN: 1879-1336 ISO Abbreviation: Cardiovasc. Pathol. Publication Date: 2010 Mar-Apr |
Date Detail:
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Created Date: 2010-02-09 Completed Date: 2010-05-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9212060 Medline TA: Cardiovasc Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 125-6 Citation Subset: IM |
Affiliation:
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Department of Anatomic Pathology, Cleveland Clinic, 9500 Euclid Avenue/L25, Cleveland, OH 44195, USA. tanc@ccf.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cardiotonic Agents
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administration & dosage*,
chemistry Enzyme Inhibitors / administration & dosage*, chemistry Humans Methylene Blue / administration & dosage*, chemistry Myocardium / chemistry, metabolism, pathology* Oxidation-Reduction Shock, Septic / drug therapy*, pathology, physiopathology Staining and Labeling |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 0/Enzyme Inhibitors; 61-73-4/Methylene Blue |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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