Document Detail


Blue dye, green heart.
MedLine Citation:
PMID:  18703358     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Methylene blue has been used for the rapid reversal of circulatory shock refractory to fluid administration, inotropic agents, and vasoconstrictors. Its clinical side effects have been well described. We report an interesting autopsy observation in patients who received methylene blue as adjunct therapy for septic shock. The exposed surface of cardiac myocardium on both fresh and fixed states rapidly turned green. In the presence of molecular oxygen, the colorless metabolite leukomethylene blue is readily oxidized to methylene blue, thus explaining the visible color change of the myocardium.
Authors:
Carmela D Tan; E Rene Rodriguez
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Publication Detail:
Type:  Journal Article     Date:  2008-08-13
Journal Detail:
Title:  Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology     Volume:  19     ISSN:  1879-1336     ISO Abbreviation:  Cardiovasc. Pathol.     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-02-09     Completed Date:  2010-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9212060     Medline TA:  Cardiovasc Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  125-6     Citation Subset:  IM    
Affiliation:
Department of Anatomic Pathology, Cleveland Clinic, 9500 Euclid Avenue/L25, Cleveland, OH 44195, USA. tanc@ccf.org
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MeSH Terms
Descriptor/Qualifier:
Cardiotonic Agents / administration & dosage*,  chemistry
Enzyme Inhibitors / administration & dosage*,  chemistry
Humans
Methylene Blue / administration & dosage*,  chemistry
Myocardium / chemistry,  metabolism,  pathology*
Oxidation-Reduction
Shock, Septic / drug therapy*,  pathology,  physiopathology
Staining and Labeling
Chemical
Reg. No./Substance:
0/Cardiotonic Agents; 0/Enzyme Inhibitors; 61-73-4/Methylene Blue

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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