Document Detail

Blood warming during hemofiltration can improve hemodynamics and outcome in ovine septic shock.
MedLine Citation:
PMID:  16732093     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study was designed to evaluate the effects of blood warming during hemofiltration on global and regional hemodynamics, plasma lactate, and 24-h survival during septic shock. METHODS: Twenty anesthetized and mechanically ventilated sheep underwent induction of peritonitis and, 4 h later, were treated by hemofiltration with (n = 10) or without (n = 10) blood warming. RESULTS: In the group without blood warming, body temperature decreased after starting hemofiltration and remained below baseline. In the other animals, body temperature stabilized at baseline level during hemofiltration and increased to a maximum of 40.8 degrees C thereafter. The group without warming experienced a decrease in blood pressure (from 90 mmHg to 38 mmHg) and cardiac output (from 4.0 l/min to 2.3 l/min). Metabolic acidosis and the increase in lactate were less marked when temperature was maintained. None of the animals without warming but all of the animals with warming survived to 16 h. CONCLUSIONS: Differences in temperature during hemofiltration resulted in striking differences in hemodynamics, metabolic acidosis, and survival rate in this clinically relevant experimental model of septic shock.
Peter Rogiers; Qinghua Sun; George Dimopoulos; Zizhi Tu; Dirk Pauwels; Cindy Manhaeghe; Fuhong Su; Jean-Louis Vincent
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesiology     Volume:  104     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-29     Completed Date:  2006-06-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1216-22     Citation Subset:  AIM; IM    
Department of Intensive Care, Middelheim General Hospital, Antwerp, Belgium.
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MeSH Terms
Acidosis, Lactic / prevention & control
Blood Pressure
Body Temperature*
Cardiac Output
Hot Temperature
Shock, Septic / mortality,  physiopathology,  therapy*
Survival Rate
Vascular Resistance

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