| Blood volume regulating hormones response during two space related simulation protocols: four-week confinement and head-down bed-rest. | |
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MedLine Citation:
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PMID: 11540581 Owner: NASA Status: MEDLINE |
Abstract/OtherAbstract:
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The volume of regulating hormones (renin, aldosterone, arginine vasopressin and atrial natriuretic factor), electrolytes and creatinine concentrations, and blood pressure were measured in two different four-week experimental protocols: respectively -6 degrees head-down bed-rest (5 subjects) and confinement (6 subjects). We observed a significant increase (P < 0.01 at D2 vs D-5) of systolic blood pressure during confinement and a different level of response for some hormones, especially for arginine vasopressin (300% increase during confinement instead of 50% during bed-rest). The renin-angiotensin-aldosterone system was enhanced during confinement and head-down bed-rest. In both conditions, we obtained a similar pattern of response for blood volume regulating hormones. During confinement, two main factors were inactivity and stress activation of the sympathetic nervous system. In the bed-rest study the response is principally due to the fluid shift and blood volume adaptation but it is not possible to exclude the role of inactivity and stress. |
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Authors:
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A Maillet; G Gauquelin; H C Gunga; J O Fortrat; K Kirsch; A Guell; Bizollon ChA; C Gharib |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta astronautica Volume: 35 ISSN: 0094-5765 ISO Abbreviation: Acta Astronaut Publication Date: 1995 Apr |
Date Detail:
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Created Date: 1998-07-06 Completed Date: 1998-07-06 Revised Date: 2007-08-01 |
Medline Journal Info:
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Nlm Unique ID: 9890631 Medline TA: Acta Astronaut Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 547-52 Citation Subset: S |
Affiliation:
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Laboratoire de Physiologie de l'Environnement, Faculte de Medicine Lyon Grange-Blanche, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aerospace Medicine Aldosterone / blood, metabolism* Arginine Vasopressin / blood, metabolism* Atrial Natriuretic Factor / blood, metabolism* Bed Rest Blood Pressure / physiology Blood Volume / physiology* Creatinine / blood, metabolism Environment, Controlled Head-Down Tilt Heart Rate / physiology Humans Male Potassium / blood, metabolism, urine Renin / blood, metabolism* Rest / physiology Sodium / blood, metabolism, urine Space Simulation* Stress, Psychological / metabolism, physiopathology Weightlessness Simulation* |
| Chemical | |
Reg. No./Substance:
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113-79-1/Arginine Vasopressin; 52-39-1/Aldosterone; 60-27-5/Creatinine; 7440-09-7/Potassium; 7440-23-5/Sodium; 85637-73-6/Atrial Natriuretic Factor; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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