Document Detail

Blood volume modeling and refilling rate estimation in hemodialysis by continuous hemoglobin monitoring.
MedLine Citation:
PMID:  8582767     Owner:  NLM     Status:  MEDLINE    
Eleven bicarbonate hemodialyses (HD) of 6 patients under constant ultrafiltration were continuously monitored with an optical Hb-meter, considered to be a marker of blood volume (BV) changes. A theoretical model was fed experimental data for prediction of blood volume and estimation of vascular parameters, and a time course of rate of refilling was extrapolated. The adequacy of the model was very good for the time course of BV prediction (r2 = 0.85-0.95, n = 11) and for plasma protein concentration (r2 = 0.83-0.86, n = 2). Parameters estimated included (mean-DS): filtration coefficient (Cf) = 0.22 (0.16) dl/min*mmHg, transcapillary hydrostatic pressure (DP) = 17.80 (3.44) mmHg and protein concentration of the refilling fluid (Cref) = 0.45 (0.30) g/dl. In conclusion our study has shown that the model chosen fits the observed BV profile well in all cases, thus the Hb data series can be used for BV dynamic modeling and for estimation of vascular parameters.
G Arrigo; R Bucci; G Colasanti; A Rustici; M Sivo; V Rizza; G D'Amico
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The International journal of artificial organs     Volume:  18     ISSN:  0391-3988     ISO Abbreviation:  Int J Artif Organs     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1996-03-21     Completed Date:  1996-03-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802649     Medline TA:  Int J Artif Organs     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  509-12     Citation Subset:  IM    
Division of Nephrology and Dialysis, Ospedale San Carlo Borromeo, Milano, Italy.
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MeSH Terms
Blood Proteins / analysis
Blood Volume / physiology*
Capillary Permeability / physiology
Hemoglobins / analysis,  metabolism*
Hypotension / etiology,  physiopathology
Middle Aged
Models, Theoretical
Monitoring, Physiologic
Renal Dialysis / adverse effects,  standards*
Reg. No./Substance:
0/Blood Proteins; 0/Hemoglobins

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