Document Detail

Blood viscosity during thrombolytic therapy with anistreplase in acute myocardial infarction.
MedLine Citation:
PMID:  8420229     Owner:  NLM     Status:  MEDLINE    
It has been postulated that a reduction in blood viscosity due to degradation of plasma fibrinogen may be of benefit to patients with acute myocardial infarction (AMI), who are treated with thrombolytic agents. The aims of this study were to investigate the time course of rheologic parameters, to identify the principal factors determining blood viscosity, and to find possible correlations between viscosity and cardiac function during thrombolytic therapy with anistreplase. Therefore, the viscosity of whole blood and plasma and the hematocrit were measured before and at 10 time points after thrombolysis in 10 patients with AMI. In addition, plasma fibrinogen and fibrin(ogen) degradation products were determined. Immediately after the start of thrombolysis, the viscosity of blood (both at high and low shear rate) and plasma decreased significantly and continued to do so for 24 hours. The mean hematocrit also decreased markedly, and even after correction for these hematocrit changes, the reduction in blood viscosity remained significant: it decreased to 72% of pretreatment (measured at low shear rate), whereas the high-shear viscosity decreased to 95% of baseline. The viscosity of plasma significantly decreased from 1.39 +/- 0.13 mPa.s (mean +/- SD) before thrombolysis to 1.22 +/- 0.08 mPa.s after 2 hours. There was a rapid, nearly complete depletion in fibrinogen, followed by a striking rebound after the second day. The decrease in blood viscosity lasted for 2 days after anistreplase and was mainly accounted for by the reduction in hematocrit. The contribution of fibrinogen to blood viscosity appeared less prominent. Despite these rheologic changes, no improvement in cardiac output was noticed in the patients.
J J Hoffmann; J J Bonnier; P G Melman; I Bartholomeus
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  71     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-02-05     Completed Date:  1993-02-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  14-8     Citation Subset:  AIM; IM    
Department of Clinical Laboratories (Hemostasis division), Catharina Hospital, Eindhoven, The Netherlands.
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MeSH Terms
Anistreplase / therapeutic use*
Blood Coagulation Factors / analysis
Blood Viscosity*
Cardiac Output / physiology
Coronary Vessels / pathology
Fibrin Fibrinogen Degradation Products / analysis
Fibrinogen / analysis
Middle Aged
Myocardial Infarction / blood*,  drug therapy*,  pathology,  physiopathology
Regression Analysis
Thrombolytic Therapy*
Vascular Patency
Reg. No./Substance:
0/Blood Coagulation Factors; 0/Fibrin Fibrinogen Degradation Products; 81669-57-0/Anistreplase; 9001-32-5/Fibrinogen

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