Document Detail


Blood vessel repair and regeneration in the ischaemic heart.
MedLine Citation:
PMID:  25332783     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The term 'therapeutic angiogenesis' originated almost two decades ago, following evidence that factors that promote blood vessel formation could be delivered to ischaemic tissues and restore blood flow. Following this proof-of-principle, safety and efficacy of the best-studied angiogenic factors (eg, vascular endothelial growth factor) were demonstrated in early clinical studies. Promising results led to the development of larger controlled trials that, unfortunately, have failed to satisfy the initial expectations of therapeutic angiogenesis for ischaemic heart disease. As the quest to delay the progression to heart failure secondary to ischaemic heart disease continues, alternative therapies have emerged as potential novel treatments to improve myocardial reperfusion and long-term heart function. The disappointing results of the clinical studies using angiogenic factors were followed by mixed results from the cell therapy trials. This review reflects the current angiogenic strategies for the ischaemic heart, their limitations and discusses future perspectives in the light of recent scientific and clinical evidence. It is proposed that combination therapies may be a new direction to advance therapeutic repair and regeneration of blood vessels in the ischaemic heart.
Authors:
Huajun Zhang; Casper van Olden; Dominic Sweeney; Enca Martin-Rendon
Related Documents :
25412643 - Correlation between endothelial dysfunction and left ventricular remodeling in patients...
1911803 - Revised technique of heterotopic heart transplantation in rabbits.
5699073 - Pathology of the heart in the tenth decade.
Publication Detail:
Type:  Journal Article     Date:  2014-02-01
Journal Detail:
Title:  Open heart     Volume:  1     ISSN:  2053-3624     ISO Abbreviation:  Open Heart     Publication Date:  2014  
Date Detail:
Created Date:  2014-10-21     Completed Date:  2014-10-21     Revised Date:  2014-10-23    
Medline Journal Info:
Nlm Unique ID:  101631219     Medline TA:  Open Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  e000016     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The reduced cost of providing a nationally recognised service for familial hypercholesterolaemia.
Next Document:  Daylight savings time and myocardial infarction.