Document Detail

Blood transfusions and the subsequent risk of cancers in the United States elderly.
MedLine Citation:
PMID:  23320915     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Blood transfusions are common in older adults and also may modulate the immune system. However, the impact of transfusion on cancer risk in the elderly has not been studied.
STUDY DESIGN AND METHODS: Cancer risk after blood transfusion was evaluated in a US population-based case-control study using 552,951 elderly cases identified from cancer registries and 100,000 frequency-matched controls. Transfusions received 0 to 12, 13 to 30, and 31 to 48 months before cancer diagnosis or selection date were identified using Medicare claims. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression models. A Bonferroni correction adjusted for multiple testing.
RESULTS: Transfusions received 0 to 12 months before cancer diagnosis and/or selection were associated with significantly elevated risk of cancer overall (OR,2.05; 95% CI, 1.95-2.16) and cancer of the stomach; cancer of the colon; cancer of the liver, kidney, renal pelvis, and/or ureter; lymphoma; myeloma; and leukemia. No significant associations for cancer overall were observed for the two earlier intervals. No site was associated with transfusions received 13 to 30 or 31 to 48 months before diagnosis and/or selection. Nonetheless, overall cancer risk increased with the number of transfused periods (p-trend<0.0001).
CONCLUSION: Risk of overall cancer and specific sites was elevated 0 to 12 months after blood transfusion and associated with multiple transfusions, possibly due to reverse causation, that is, incipient cancers or cancer precursors causing anemia.
Regina Riedl; Eric A Engels; Joan L Warren; Andrea Berghold; Winnie Ricker; Ruth M Pfeiffer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2013-01-16
Journal Detail:
Title:  Transfusion     Volume:  53     ISSN:  1537-2995     ISO Abbreviation:  Transfusion     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-08     Completed Date:  2013-12-04     Revised Date:  2014-10-12    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2198-206     Citation Subset:  IM    
Copyright Information:
© 2013 American Association of Blood Banks.
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MeSH Terms
Aged, 80 and over
Blood Transfusion / adverse effects*
Case-Control Studies
Logistic Models
Neoplasms / etiology*
Odds Ratio
Time Factors
United States
Grant Support
Z01 CP010182-05/CP/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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