Document Detail

Blood transfusion, skin test reactivity, and lymphocytes in inflammatory bowel disease.
MedLine Citation:
PMID:  3485387     Owner:  NLM     Status:  MEDLINE    
Peripheral lymphocytes, T and B cell counts, and skin test reactivity to five recall antigens were determined before operation and 6 to 18 months after operation with or without blood transfusion in 59 patients with inflammatory bowel disease. Significantly reduced preoperative peripheral lymphocyte and T cell counts reached normal levels 6 to 18 months after operation in patients who had not received perioperative blood transfusions. However, lymphocytes and T cells of transfused patients remained decreased, unchanged from preoperative levels, and significantly lower than those of control subjects (p less than 0.005) and levels of patients who had not been transfused (p less than 0.05). Before operation, transfused and untransfused patients were identical in age, Crohn's disease activity index, and peripheral lymphocyte and T and B cell counts. Equal numbers of patients were taking steroids and were anergic to skin tests with five recall antigens. Transfused patients weighed less preoperatively than untransfused patients, and these patients then gained a significant amount of weight. These results suggest that some of the immunologic abnormalities that accompany inflammatory bowel disease may be influenced by blood transfusions.
P I Tartter; T M Heimann; A H Aufses
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of surgery     Volume:  151     ISSN:  0002-9610     ISO Abbreviation:  Am. J. Surg.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-04-11     Completed Date:  1986-04-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370473     Medline TA:  Am J Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  358-61     Citation Subset:  AIM; IM    
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MeSH Terms
B-Lymphocytes / immunology
Blood Transfusion*
Body Weight
Colitis, Ulcerative / immunology*,  surgery,  therapy
Crohn Disease / immunology*,  surgery,  therapy
Immune Tolerance
Leukocyte Count
Lymphocytes / immunology*
Prospective Studies
Skin Tests*
T-Lymphocytes / immunology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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