Document Detail


Blood transfusion in marrow graft recipients.
MedLine Citation:
PMID:  1511059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Of 182 consecutive patients undergoing allogeneic bone marrow transplantation (BMT), the relative numbers of those who received red blood cells (RBC), platelets (PLT), and granulocytes were 82%, 96%, and 26%, respectively. The transfused patients received an average of 1.26 (SD +/- 2.0) RBC units, 9.41 (SD +/- 13.2) PLT transfusions, and 0.33 (SD +/- 1.1) granulocyte concentrates per week per 50 kg body wt. in the period starting on the day of bone marrow transplantation (BMT) up to 60 days post BMT. The total number of units per transfused patient was 7.7 (range 1-63) RBC, 55.2 (range 2-394) PLT and 6.2 (range 1-36) granulocytes in the same period. Patients with grades II-IV acute graft-versus-host disease (GVHD) needed more RBC and PLT (p less than 0.001) than patients with grades 0-I acute GVHD. Patients with late engraftment required more granulocyte and PLT transfusion than those with early engraftment (p less than 0.05). Patients with high-risk malignancy had greater need for RBC and PLT than "low-risk patients" (p less than 0.02 and p less than 0.01), respectively). Patients with major ABO-incompatible donors showed a greater need for RBC than patients with minor ABO incompatibility (p = 0.02) or ABO identical donors (p = 0.01). Patients with relatively poor estimated survival required the most RBC and PLT.
Authors:
P Pihlstedt; T Paulin; B Sundberg; B Nilsson; O Ringdén
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of hematology     Volume:  65     ISSN:  0939-5555     ISO Abbreviation:  Ann. Hematol.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-09-28     Completed Date:  1992-09-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9107334     Medline TA:  Ann Hematol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  66-70     Citation Subset:  IM    
Affiliation:
Blood Bank, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
ABO Blood-Group System
Adolescent
Adult
Blood Component Transfusion
Blood Group Incompatibility
Blood Grouping and Crossmatching
Blood Transfusion*
Bone Marrow Transplantation* / mortality
Child
Child, Preschool
Female
Humans
Infant
Male
Middle Aged
Survival Rate
Chemical
Reg. No./Substance:
0/ABO Blood-Group System

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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