Document Detail


Blood-tissue transport of exogenous albumin and immunoglobulin G in genetically analbuminemic rats.
MedLine Citation:
PMID:  7681428     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tracer uptake studies were carried out in adult female Nagase (NA) strain analbuminemic rats [derived from Sprague-Dawley (SD) stock] and in adult female SD controls to determine the extent to which capillary permeability to plasma proteins is altered in the absence of endogenous albumin. Accessory measurements (arterial pressure, central venous pressure, plasma and interstitial fluid protein concentrations and oncotic pressures, plasma volume, and interstitial fluid volume) confirm the report of Joles et al. [Am. J. Physiol. 257 (Renal Fluid Electrolyte Physiol. 26): F23-F28, 1989] that shows elevated plasma volumes, normal interstitial fluid volumes, nearly normal plasma oncotic pressures (due to elevated globulin concentrations), and lower interstitial fluid oncotic pressures. In skin, skeletal muscles, and heart muscle, clearances of exogenous heterologous (bovine) albumin were 20-40% higher in NA than in SD controls. In intestine, albumin clearances were 20-30% lower. In NA rats blood-to-tissue clearances of heterologous (bovine) immunoglobulin G in skin and heart were higher and in the intestine they were lower than in SD controls; however, clearances in skeletal muscles were not elevated. The differences between NA and SD are small compared with the large increases in macromolecular permeabilities reported by others for organs and single microvessels perfused with albumin-free fluids.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
E M Renkin; V L Tucker; H Wiig; G Kaysen; L Sibley; M DeCarlo; K Simanonok; M Wong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  74     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-04-27     Completed Date:  1993-04-27     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  559-66     Citation Subset:  IM    
Affiliation:
Department of Human Physiology, School of Medicine, University of California, Davis 95616.
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MeSH Terms
Descriptor/Qualifier:
Albumins / metabolism*,  pharmacology
Animals
Blood Proteins / metabolism
Capillary Permeability / drug effects
Extracellular Space / metabolism
Female
Immunoglobulin G / metabolism*
Rats
Rats, Inbred Strains
Rats, Sprague-Dawley
Serum Albumin / deficiency*
Serum Albumin, Radio-Iodinated
Tissue Distribution
gamma-Globulins / pharmacology
Grant Support
ID/Acronym/Agency:
DK-42297/DK/NIDDK NIH HHS; H-107957//PHS HHS; HL-18010/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Albumins; 0/Blood Proteins; 0/Immunoglobulin G; 0/Serum Albumin; 0/Serum Albumin, Radio-Iodinated; 0/gamma-Globulins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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