Document Detail

Blood and tissue levels of lipoperoxides in rats during development.
MedLine Citation:
PMID:  7066447     Owner:  NLM     Status:  MEDLINE    
The excessive accumulation of lipoperoxides has been accepted as being highly responsible for the development of retinopathy of prematurity and idiopathic respiratory distress syndrome of the newborn infant. We have studied development-related levels of lipoperoxides in blood and tissues such as the liver, lungs, kidneys and brain from birth to adult age using rats as the experimental animal. Lipoperoxide concentrations in blood and tissues were low in fetal and early newborn periods. The concentrations increased with age and peaked in the early newborn period and gradually decreased as the development progressed. In vitro lipoperoxide formation and accumulation in tissues exhibited a close correlation with in vivo lipoperoxide concentrations, except in the brain.
T Yoshioka; M Mori; Y Takehara; M Shimatani
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biology of the neonate     Volume:  41     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1982  
Date Detail:
Created Date:  1982-06-21     Completed Date:  1982-06-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  155-60     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn / metabolism*
Brain / metabolism
Fetal Blood / metabolism*
Fetus / metabolism*
Kidney / metabolism
Lipid Peroxides / blood,  metabolism*
Liver / metabolism
Lung / metabolism
Rats, Inbred Strains
Reg. No./Substance:
0/Lipid Peroxides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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