| Blood is thicker than lymph. | |
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MedLine Citation:
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PMID: 18097477 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Growth of blood and lymphatic vessels is essential in the developing embryo and in the pathogenesis of human diseases such as cancer, but the signaling pathways that regulate vessel growth and function are not yet well characterized. In this issue of the JCI, studies by Fritz-Six et al. and Ichikawa-Shindo et al. demonstrate that loss of signaling by the adrenomedullin peptide results in embryonic edema and death (see the related articles beginning on pages 40 and 29, respectively). Remarkably, this phenotype is attributed to defects in lymphatic vessels by one group and to defects in blood vessels by the other. In addition to defining what I believe to be a novel angiogenic signaling pathway, these studies demonstrate the intricate molecular, genetic, and physiologic relationships between blood and lymphatic vessels that must be considered by investigators of vascular biology. |
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Authors:
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Mark L Kahn |
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Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 118 ISSN: 0021-9738 ISO Abbreviation: J. Clin. Invest. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-03 Completed Date: 2008-04-14 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 23-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine and University of Pennsylvania Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. markkahn@mail.med.upenn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenomedullin
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genetics,
metabolism* Animals Arteries / metabolism, pathology Capillary Permeability / physiology* Cardiovascular Diseases / genetics, metabolism, pathology Cells, Cultured Edema / genetics, metabolism, pathology Embryo Loss / genetics, metabolism, pathology Embryonic Stem Cells / metabolism, pathology Endothelium, Vascular / metabolism, pathology Female Homeostasis / physiology* Humans Intracellular Signaling Peptides and Proteins / genetics Male Membrane Proteins / biosynthesis*, genetics Mice Mice, Knockout Neovascularization, Physiologic / physiology* Pregnancy Receptors, Calcitonin / genetics, metabolism Receptors, Peptide / genetics, metabolism* Tight Junctions / genetics, metabolism, pathology |
| Chemical | |
Reg. No./Substance:
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0/Intracellular Signaling Peptides and Proteins; 0/Membrane Proteins; 0/Receptors, Calcitonin; 0/Receptors, Peptide; 0/adrenomedullin receptor; 0/calcitonin receptor-like receptor; 0/receptor-activity-modifying protein; 148498-78-6/Adrenomedullin |
| Comments/Corrections | |
Comment On:
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J Clin Invest. 2008 Jan;118(1):40-50
[PMID:
18097475
]
J Clin Invest. 2008 Jan;118(1):29-39 [PMID: 18097473 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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