| Blood substitutes. What they are and how they might be used. | |
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MedLine Citation:
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PMID: 14569814 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Three classes of materials have been studied as potential blood substitutes: modified hemoglobin solutions, perfluorocarbon emulsions, and liposome-encapsulated hemoglobin. The first two have reached phase III clinical trials, while the third remains in the preclinical state of testing. Hemoglobin is a highly active molecule; hence, modification has been required to avoid potential deleterious effects. Although there has been considerable progress toward bringing such a product to the clinical setting, its development has challenged our understanding of oxygen delivery and use. The perfluorocarbon emulsions have been studied primarily for roles other than as equivalents of conventional banked units of RBCs for transfusion. The study of these molecules has added to our understanding of basic physiologic processes. |
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Authors:
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Qun Dong; Christopher P Stowell |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American journal of clinical pathology Volume: 118 Suppl ISSN: 0002-9173 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2003-10-22 Completed Date: 2003-11-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: United States |
Other Details:
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Languages: eng Pagination: S71-80 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Substitutes* Clinical Trials as Topic Fluorocarbons / adverse effects, chemistry, pharmacokinetics, therapeutic use Hemoglobins / adverse effects, chemistry, pharmacokinetics, therapeutic use Humans Liposomes |
| Chemical | |
Reg. No./Substance:
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0/Blood Substitutes; 0/Fluorocarbons; 0/Hemoglobins; 0/Liposomes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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