Document Detail


Blood selenium and glutathione peroxidases in miscarriage.
MedLine Citation:
PMID:  11281462     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the selenium glutathione and glutathione peroxidase (glutathione-Px) levels in blood in women who experience miscarriage. DESIGN: An observational study. PARTICIPANTS: Forty women with miscarriage occurring in the first and second trimesters. METHODS: Concentrations were measured in whole blood and plasma. Glutathione was measured in red cells and glutathione-Px activity was measured in the red cells and plasma. The results were compared with 36 women in the same period of viable pregnancy and 28 age-matched, healthy, non-pregnant controls. RESULTS: The selenium concentrations in whole blood and plasma of women following abortion were the same as in viable pregnancy, but were significantly lower compared with controls. The glutathione levels were significantly higher in women with miscarriage compared with viable pregnancies and with non-pregnant women. Red cell and plasma glutathione-Px activities of women who had had a miscarriage were significantly lower than in both normal pregnancies and the control group. CONCLUSION: The decreased activities of the antioxidant enzymes, red cell and plasma glutathione-Px, may play an important role in the aetrology of spontaneous abortion.
Authors:
B A Zachara; W Dobrzyński; U Trafikowska; W Szymański
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  108     ISSN:  1470-0328     ISO Abbreviation:  BJOG     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-04-02     Completed Date:  2001-04-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  244-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Biochemistry, The Ludwik Rydygier Medical University, Bydgoszcz, Poland.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / blood,  enzymology,  prevention & control*
Adolescent
Adult
Biological Markers / blood
Cohort Studies
Erythrocytes / chemistry
Female
Glutathione / blood*
Glutathione Peroxidase / blood*
Humans
Pregnancy
Pregnancy Trimester, First / blood
Pregnancy Trimester, Second / blood
Selenium / blood*,  deficiency
Chemical
Reg. No./Substance:
0/Biological Markers; 70-18-8/Glutathione; 7782-49-2/Selenium; EC 1.11.1.9/Glutathione Peroxidase

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