Document Detail

Blood rheology in acute myocardial infarction: effects of high-dose i.v. streptokinase compared to placebo.
MedLine Citation:
PMID:  1555628     Owner:  NLM     Status:  MEDLINE    
To compare the haemorheological effects of an i.v. infusion of 1.5 MU of streptokinase with placebo, we investigated the time course of plasma fibrinogen concentration and the haemorheologic parameters plasma viscosity, erythrocyte aggregation and whole blood viscosity at different shear rates during the early phase of acute myocardial infarction until week 3 in 38 unselected patients from the ISAM and ISIS-2 study. Within 3 h, streptokinase led to a near afibrinogenaemia lasting for more than 24 h. Concomitantly, with streptokinase we found a reduction of plasma viscosity, erythrocyte aggregation and whole blood viscosity, whereas with placebo, values showed a slight increase, resulting in significant differences between the groups within the first 2 days. Thereafter, both groups showed an increase in all parameters, values reaching a maximum after 1 week. The streptokinase-induced reduction in blood viscosity may lead to an improvement in microcirculation in the infarction area during the early phase, whereas the hyperviscosity observed independently of therapy after 1 week may lead to an impairment of microcirculation.
H R Arntz; G Perchalla; D Roll; J Heitz; J H Schäfer; R Schröder
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European heart journal     Volume:  13     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-05-01     Completed Date:  1992-05-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  275-80     Citation Subset:  IM    
Department of Cardiopulmonary, Free University of Berlin, F.R.G.
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MeSH Terms
Blood Flow Velocity / drug effects,  physiology
Blood Viscosity / drug effects*,  physiology
Dose-Response Relationship, Drug
Electrocardiography / drug effects
Erythrocyte Aggregation / drug effects,  physiology
Fibrinogen / metabolism
Infusions, Intravenous
Middle Aged
Myocardial Infarction / blood,  drug therapy*
Streptokinase / administration & dosage*
Reg. No./Substance:
9001-32-5/Fibrinogen; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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