| Blood protein concentrations in the first two postnatal weeks that predict bronchopulmonary dysplasia among infants born before the 28th week of gestation. | |
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MedLine Citation:
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PMID: 21150694 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lung inflammation contributes to the pathogenesis of bronchopulmonary dysplasia (BPD) and may be accompanied by a systematic inflammatory response. The objective of this study was to investigate the role of systemic inflammation in the development of BPD in a cohort of extremely low GA newborns (ELGANs) by examining the relationships between inflammation-associated proteins in neonatal blood samples and pulmonary outcomes. Proteins were measured in blood specimens collected on postnatal d 1-3, 5-8, and 12-15 from 932 ELGANs. Increased risk of BPD was associated with elevated blood concentrations of a variety of proinflammatory cytokines, adhesion molecules, and proteases. Reduced risk was prominently associated with increased concentrations of one chemokine, RANTES. Elevations of inflammatory proteins associated with BPD risk occurred during the first days after birth and inflammation intensified thereafter. Therefore, exposures that promote inflammation after the first postnatal days may be more critical in the pathogenesis of BPD. Fetal growth restriction, a known BPD risk factor, was not accompanied by proteins elevations and therefore does not seem to be mediated by systemic inflammation. By contrast, mechanical ventilation altered protein levels and may be associated with systemic inflammation |
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Authors:
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Carl Bose; Matthew Laughon; Elizabeth N Allred; Linda J Van Marter; T Michael O'Shea; Richard A Ehrenkranz; Raina Fichorova; Alan Leviton; |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric research Volume: 69 ISSN: 1530-0447 ISO Abbreviation: Pediatr. Res. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-12 Completed Date: 2011-06-13 Revised Date: 2012-09-19 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 347-53 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA. cbose@med.unc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Proteins* Bronchopulmonary Dysplasia / blood*, etiology Chemokines / blood, immunology Cohort Studies Cytokines / blood, immunology Female Gestational Age* Humans Infant, Newborn / blood* Infant, Premature / blood* Odds Ratio Pneumonia / blood*, complications Pregnancy Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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5U01NS040069-04/NS/NINDS NIH HHS; U01 NS040069-04/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Chemokines; 0/Cytokines |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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