Document Detail

Blood protein concentrations in the first two postnatal weeks that predict bronchopulmonary dysplasia among infants born before the 28th week of gestation.
MedLine Citation:
PMID:  21150694     Owner:  NLM     Status:  MEDLINE    
Lung inflammation contributes to the pathogenesis of bronchopulmonary dysplasia (BPD) and may be accompanied by a systematic inflammatory response. The objective of this study was to investigate the role of systemic inflammation in the development of BPD in a cohort of extremely low GA newborns (ELGANs) by examining the relationships between inflammation-associated proteins in neonatal blood samples and pulmonary outcomes. Proteins were measured in blood specimens collected on postnatal d 1-3, 5-8, and 12-15 from 932 ELGANs. Increased risk of BPD was associated with elevated blood concentrations of a variety of proinflammatory cytokines, adhesion molecules, and proteases. Reduced risk was prominently associated with increased concentrations of one chemokine, RANTES. Elevations of inflammatory proteins associated with BPD risk occurred during the first days after birth and inflammation intensified thereafter. Therefore, exposures that promote inflammation after the first postnatal days may be more critical in the pathogenesis of BPD. Fetal growth restriction, a known BPD risk factor, was not accompanied by proteins elevations and therefore does not seem to be mediated by systemic inflammation. By contrast, mechanical ventilation altered protein levels and may be associated with systemic inflammation
Carl Bose; Matthew Laughon; Elizabeth N Allred; Linda J Van Marter; T Michael O'Shea; Richard A Ehrenkranz; Raina Fichorova; Alan Leviton;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  69     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-12     Completed Date:  2011-06-13     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  347-53     Citation Subset:  IM    
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MeSH Terms
Blood Proteins*
Bronchopulmonary Dysplasia / blood*,  etiology
Chemokines / blood,  immunology
Cohort Studies
Cytokines / blood,  immunology
Gestational Age*
Infant, Newborn / blood*
Infant, Premature / blood*
Odds Ratio
Pneumonia / blood*,  complications
Risk Factors
Grant Support
5U01NS040069-04/NS/NINDS NIH HHS; U01 NS040069/NS/NINDS NIH HHS; U01 NS040069-04/NS/NINDS NIH HHS
Reg. No./Substance:
0/Blood Proteins; 0/Chemokines; 0/Cytokines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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