Document Detail

Blood pressures in newborns with twin-twin transfusion syndrome.
MedLine Citation:
PMID:  21252959     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: In addition to unbalanced flow through placental anastomoses, evidence suggests that transfer of circulating vasoactive elements from the donor to the recipient contribute to the pathological process of twin-twin transfusion syndrome (TTTS). The objective of this study was to test the hypothesis that TTTS recipients have higher blood pressure (BP) at birth than donors.
STUDY DESIGN: Chart review of all TTTS infants born from 1996 to 2007 with both twins alive 24 h (51 pairs; average gestational age 30±3 weeks).
RESULTS: Both systolic and diastolic neonatal BPs were significantly higher in recipients. When expressed relative to predicted BP for birth weight (BW), BP were lower than expected in donors and higher in recipients.
CONCLUSIONS: Data indicate that TTTS recipients have BP significantly higher than donors and than BP expected for BW. The long-term impact of these early hemodynamic perturbations remains to be determined.
I Mercanti; A Boivin; B Wo; V Vlieghe; C Le Ray; F Audibert; J-C Fouron; L Leduc; A M Nuyt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-01-20
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  31     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-27     Completed Date:  2011-11-14     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  417-24     Citation Subset:  IM    
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MeSH Terms
Angiotensin II / blood
Apgar Score
Birth Weight
Blood Pressure / physiology*
Cardiomegaly / mortality,  physiopathology,  therapy
Critical Care
Fetofetal Transfusion / mortality,  physiopathology*,  therapy
Gestational Age
Heart Ventricles / physiopathology
Infant, Newborn
Survival Rate
Grant Support
//Canadian Institutes of Health Research
Reg. No./Substance:
11128-99-7/Angiotensin II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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