Document Detail

Blood pressure and white matter integrity in geriatric depression.
MedLine Citation:
PMID:  18805589     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cerebrovascular disease may increase vulnerability to geriatric depression, a syndrome often accompanied by frontal-subcortical lesions. High blood pressure is a risk factor for cerebrovascular disease and white matter changes. This study examined whether and in which brain regions blood pressure is associated with compromised white matter integrity in elderly depressed patients.
METHODS: We studied the association between blood pressure and white matter integrity assessed by diffusion tensor imaging (fractional anisotropy, FA) in 41 older patients with major depression. Correlations between FA and blood pressure, after controlling for age, were examined with a voxelwise analysis.
RESULTS: Significant associations between FA and blood pressure were detected throughout the anterior cingulate and in multiple frontostriatal and frontotemporal regions.
LIMITATIONS: This study did not employ a healthy control group. Moreover, the relatively small sample size precluded a comparison of patients with and without hypertension.
CONCLUSIONS: Compromised frontal-striatal white matter integrity may be the anatomical background through which blood pressure confers vulnerability to depression.
Matthew J Hoptman; Faith M Gunning-Dixon; Christopher F Murphy; Babak A Ardekani; Jan Hrabe; Kelvin O Lim; Glenda R Etwaroo; Dora Kanellopoulos; George S Alexopoulos
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-09-20
Journal Detail:
Title:  Journal of affective disorders     Volume:  115     ISSN:  1573-2517     ISO Abbreviation:  J Affect Disord     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-03-30     Completed Date:  2009-06-25     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  7906073     Medline TA:  J Affect Disord     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  171-6     Citation Subset:  IM    
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MeSH Terms
Age Factors
Aged, 80 and over
Antidepressive Agents, Second-Generation / therapeutic use
Blood Pressure / physiology*
Brain / pathology*
Citalopram / therapeutic use
Depressive Disorder / diagnosis,  drug therapy,  pathology*
Depressive Disorder, Major / diagnosis,  pathology*
Diffusion Magnetic Resonance Imaging*
Dominance, Cerebral / physiology
Frontal Lobe / pathology
Gyrus Cinguli / pathology
Hypertension / diagnosis,  pathology
Image Processing, Computer-Assisted*
Mental Status Schedule
Middle Aged
Nerve Fibers, Myelinated / pathology*
Personality Inventory
Reference Values
Risk Factors
Temporal Lobe / pathology
Grant Support
K23 MH067702/MH/NIMH NIH HHS; K23 MH067702-05/MH/NIMH NIH HHS; K23 MH074818/MH/NIMH NIH HHS; K23 MH074818/MH/NIMH NIH HHS; K23 MH074818-04/MH/NIMH NIH HHS; P30 MH068638/MH/NIMH NIH HHS; P30 MH068638-04/MH/NIMH NIH HHS; P30 MH68638/MH/NIMH NIH HHS; R01 MH065653/MH/NIMH NIH HHS; R01 MH065653-04/MH/NIMH NIH HHS; R01 MH65653/MH/NIMH NIH HHS
Reg. No./Substance:
0/Antidepressive Agents, Second-Generation; 0DHU5B8D6V/Citalopram

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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