Document Detail


Blood pressure variability responses to tilt are buffered by cardiac autonomic control.
MedLine Citation:
PMID:  9321834     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Variability in blood pressure (BPV) is influenced by vascular sympathetic drive as well as autonomic control of the heart. Evidence suggests that elimination of cardiac autonomic control, as measured by heart period variability (HPV), produces a reduction in BPV at rest but an increase in BPV during challenge. We recently showed that the BPV response to psychological challenge, which principally produces cardiac parasympathetic withdrawal, was inversely related to the subject's level of cardiac control. In the current study we examined the BPV response to orthostatic tilt, a sympathetic stressor. Subjects were 22 healthy men and women who differed in cardiac control due in part to differences in aerobic capacity. HPV and BPV were measured noninvasively on a beat-to-beat basis. Tilt produced significant increases in heart rate and diastolic blood pressure and a significant decrease in high frequency HPV. As predicted, changes in BPV in response to tilt were inversely related to resting HPV. Results are interpreted in terms of a model of cardiovascular control which holds that BPV originates from feedforward effects of central control of the heart, feedback effects mediated through the baroreflexes, and direct sympathetic vascular effects.
Authors:
R P Sloan; R E DeMeersman; P A Shapiro; E Bagiella; D Chernikhova; J P Kuhl; A S Zion; M Paik; M M Myers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  273     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-23     Completed Date:  1997-10-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1427-31     Citation Subset:  IM; S    
Affiliation:
Behavioral Medicine Program, Columbia-Presbyterian Medical Center, New York, New York, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure*
Diastole
Electrocardiography*
Exercise Test
Female
Head-Down Tilt
Heart / innervation*
Heart Rate*
Humans
Male
Oxygen Consumption
Posture*
Respiration
Systole
Tilt-Table Test
Grant Support
ID/Acronym/Agency:
M01-RR-00645/RR/NCRR NIH HHS; MH-01035/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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