Document Detail

Blood pressure variability and its implications for antihypertensive therapy.
MedLine Citation:
PMID:  7735498     Owner:  NLM     Status:  MEDLINE    
Although it is clear that antihypertensive treatment is beneficial in reducing stroke morbidity and mortality, the results of the major outcome studies show less impact on coronary heart disease. Studies utilizing 24-h blood pressure (BP) monitoring show a positive association between target organ damage and the level of 24-h BP, and with variability in BP, which is an independent determinant of target organ damage. Current understanding of the pathogenesis and pathophysiology of coronary heart disease suggests that optimal antihypertensive treatment should ensure the following: effective 24-h BP control, smooth antihypertensive effect with reduced variability; attenuation of the early morning surge in BP; maintenance of the normal circadian pattern of BP; effective therapeutic coverage in the face of suboptimal compliance; and lack of reflex activation of the sympathetic nervous system. On the basis of our current understanding, this optimum is most likely to be achieved by the use of antihypertensive agents with a long duration of action.
P A Meredith; D Perloff; G Mancia; T Pickering
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Blood pressure     Volume:  4     ISSN:  0803-7051     ISO Abbreviation:  Blood Press.     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-06-08     Completed Date:  1995-06-08     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  5-11     Citation Subset:  IM    
Department of Medicine and Therapeutics, University of Glasgow, Scotland.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Blood Pressure*
Blood Pressure Monitoring, Ambulatory
Hypertension / drug therapy*,  pathology,  physiopathology*
Reg. No./Substance:
0/Antihypertensive Agents

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