Document Detail

Blood pressure variability as well as blood pressure level is important for left ventricular hypertrophy and brachial-ankle pulse wave velocity in hypertensives.
MedLine Citation:
PMID:  20001459     Owner:  NLM     Status:  MEDLINE    
Blood pressure (BP) variability is calculated as the standard deviation of ambulatory BP. Blood pressure variability is associated with the cardiovascular morbidity; however whether it is related to target organ damage is controversial. In this study we examined a possible relationship between the BP variability and left ventricular hypertrophy (LVH), and between BP variability and brachial-ankle pulse wave velocity (baPWV). The present study was conducted on 111 consecutive Japanese hypertensive patients who were hospitalized for the educational program in our hospital under stable sodium chloride intake (6 g/day). Blood pressure measurements were at 30-minute intervals all day. In a multivariable analysis adjusted with confounding factor, LVH was associated with 24-hour systolic BP (SBP), 24 hour diastolic BP (DBP), daytime SBP, daytime DBP, nighttime SBP, and nighttime DBP. Additionally, nighttime DBP variability was related to LVH. By the same method, baPWV as a dependent variable was related to 24-hour SBP and nighttime SBP. Furthermore, nighttime SBP variability was concerned with baPWV. The LVH was associated with not only BP level but also with nighttime DBP variability. The baPWV was also related not only to BP level but also to nighttime SBP variability.
Motoko Ozawa; Kouichi Tamura; Yasuko Okano; Kouhei Matsushita; Yuko Ikeya; Shinichiro Masuda; Hiromichi Wakui; Toru Dejima; Atsu-ichiro Shigenaga; Koichi Azuma; Tomoaki Ishigami; Yoshiyuki Toya; Toshiyuki Ishikawa; Satoshi Umemura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  31     ISSN:  1525-6006     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-03-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  669-79     Citation Subset:  IM    
Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-Ku,Yokohama, Japan.
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MeSH Terms
Ankle Brachial Index*
Blood Pressure*
Blood Pressure Determination / methods*
Blood Pressure Monitoring, Ambulatory / methods
Circadian Rhythm
Hypertension / complications,  diagnosis,  physiopathology*
Hypertrophy, Left Ventricular / diagnosis,  etiology,  physiopathology*
Middle Aged
Multivariate Analysis
Retrospective Studies
Risk Assessment
Risk Factors
Severity of Illness Index

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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