Document Detail


Blood pressure treatment target in patients with diabetes mellitus-current evidence.
MedLine Citation:
PMID:  22713147     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Abstract Hypertension is a very common cardiovascular disease (CVD) risk factor in diabetes, affecting more than half of diabetic patients. Major guidelines on the management of hypertension recommend to start antihypertensive drugs in all diabetic patients with a systolic blood pressure (SBP) 140 mmHg or more and/or a diastolic blood pressure (DBP) 90 mmHg or more, and to adjust the treatment strategy in order to lower their BP below these values. The present body of evidence suggests that in patients with type 2 diabetes mellitus/impaired fasting glucose/impaired glucose tolerance, a SBP treatment goal of 130 to 135 mmHg is acceptable. Aiming at SBP levels of 130 mmHg decreases stroke risk, but the risk of serious adverse events may increase with very low BP levels. The results regarding the attained DBP level is somewhat complex, since middle-aged people with diastolic hypertension and pre-existing CVD may have increased CVD mortality if their DBP is lowered drastically to a very low level. With the currently available very limited trial data on low attained BP level, it is not possible to set a specific treatment target regarding BP levels for diabetic hypertensive patients, but it is important to use a personalized approach in their antihypertensive treatment.
Authors:
Noël C Barengo; Jaakko O Tuomilehto
Related Documents :
1724187 - Insulin modulation of acute-phase protein production in a human hepatoma cell line.
3512337 - Insulin induces progressive insulin resistance in cultured rat adipocytes. sequential e...
18793157 - Role of nuclear receptors in the modulation of insulin secretion in lipid-induced insul...
2423467 - Stimulatory and cytotoxic effects of an antiserum to adipocyte plasma membranes on adip...
18418237 - Prevalence of subclinical atherosclerosis in asymptomatic diabetic patients by 64-slice...
9189037 - Painful proximal diabetic neuropathy: inflammatory nerve lesions and spontaneous favora...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of medicine     Volume:  44 Suppl 1     ISSN:  1365-2060     ISO Abbreviation:  Ann. Med.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8906388     Medline TA:  Ann Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  S36-42     Citation Subset:  IM    
Affiliation:
Institute of Clinical Medicine/Internal Medicine, University of Oulu , Oulu , Finland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A change in paradigm: Lowering blood pressure in everyone over a certain age.
Next Document:  Prorenin receptor regulates more than the renin-angiotensin system.