Document Detail

Blood pressure threshold violations in the first 24 hours after admission for acute stroke: frequency, timing, predictors, and impact on clinical outcome.
MedLine Citation:
PMID:  19008471     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Admission blood pressure (BP) and significant decreases in BP after acute stroke have been correlated with outcome. Few data are available on the impact of extreme values at any time point within the first 24 hours. METHODS: BP was measured hourly for 24 hours in 325 consecutive patients with acute ischemic stroke. Predefined endpoints were systolic BP >or=200, diastolic BP >or=110, or systolic BP <100 mm Hg during the first 24 hours, and significant systolic BP decreases by >26 mm Hg within 4 hours after admission. Multiple logistic regression analysis identified independent predictors of each end point and determined the impact on dependency at 3 months defined as modified Rankin scale score >or=3. RESULTS: Upper threshold violations occurred in 70% of cases during the admission process, and more frequently in patients arriving early after stroke; 30% of cases exhibited such values at a later time point. History of hypertension (P<0.01) and higher NIHSS on admission (P<0.05) were independent predictors. Systolic BP <100 mm Hg occurred at random and was associated with younger age (P<0.05). Night time admission was the strongest independent predictor of systolic BP decreases >26 mm Hg (P<0.0001). Diabetes, NIHSS on admission, and age were associated with adverse outcome at 3 months, whereas threshold violations and decreases were not. There was a trend for administration of antihypertensives being associated with poor outcome (P<0.1). CONCLUSIONS: External stimuli, premorbid risk factors, diurnal BP variations, and disease-immanent mechanisms all influence the course of BP after acute stroke. Monitoring should precede any medical BP treatment.
Martin A Ritter; Peter Kimmeyer; Peter U Heuschmann; Rainer Dziewas; Ralf Dittrich; Darius G Nabavi; E Bernd Ringelstein
Publication Detail:
Type:  Journal Article     Date:  2008-11-13
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  40     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-27     Completed Date:  2009-02-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  462-8     Citation Subset:  IM    
Department of Neurology, University of Münster, Münster, Germany.
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MeSH Terms
Age Factors
Blood Pressure / physiology*
Circadian Rhythm
Data Collection
Data Interpretation, Statistical
Endpoint Determination
Factor Analysis, Statistical
Follow-Up Studies
Logistic Models
Middle Aged
Predictive Value of Tests
Regression Analysis
Risk Factors
Sex Factors
Stroke / epidemiology,  physiopathology*,  therapy*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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