Document Detail

Blood pressure and sympathetic nervous function in spontaneously hypertensive rats derived from breeders on low sodium diet.
MedLine Citation:
PMID:  3546767     Owner:  NLM     Status:  MEDLINE    
We investigated the effect of dietary salt restriction in spontaneously hypertensive rat (SHR) breeders to determine if the development of hypertension of offspring would be blunted. Weaning SHRs (F-0) were divided into 3 groups and were given a diets containing sodium of 0.4% (G 1), 0.05% (G 2), or 0.4% plus mefruside 0.001% (G 3) with distilled water. Potassium content was 0.75% and the other ingredients except chloride were identical in all the diets. Offsprings (F-1) were derived from selective inbreeding within each group. Systolic blood pressure rose over 160 mmHg by 8 weeks of age in all the male rats of all the groups in both F-0 and F-1. There was no difference in blood pressure between G 1 and G 2 at any age, while in G 3 blood pressure was significantly lower than in G 1 at 12 and 20 weeks of age in F-1. The findings in pressure were ascertained by heart-body weight ratio determined at autopsy, which was similar between G 1 and G 2, and was smaller in G 3 than the others at 20 weeks of age. Aldostrone excretion rate was markedly higher in G 2 than G 1 and G 3 at all study points, whereas plasma renin content was similar between G 1 and G 2, and higher in G 3. Plasma concentrations of noradrenaline and adrenaline did not differ among the 3 groups at any age in both F-0 and F-1.(ABSTRACT TRUNCATED AT 250 WORDS)
K Fukiyama; S Takishita; T Eto; Y Kimura; Y Tomita; N Kawazoe; T Omae; T Tsumagari; K Onishi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  50     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1987-04-10     Completed Date:  1987-04-10     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1170-3     Citation Subset:  IM    
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MeSH Terms
Blood Pressure*
Cardiovascular System / drug effects
Diet, Sodium-Restricted*
Hexamethonium Compounds / pharmacology
Hypertension / prevention & control
Norepinephrine / blood,  pharmacology
Rats, Inbred SHR / physiology*
Rats, Inbred Strains / physiology*
Renin / blood
Sympathetic Nervous System / drug effects,  physiology*
Reg. No./Substance:
0/Hexamethonium Compounds; 51-41-2/Norepinephrine; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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