Document Detail


Blood pressure support in extremely premature infants is affected by different courses of antenatal steroids.
MedLine Citation:
PMID:  19500082     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine the effects of partial, single and multiple courses of antenatal corticosteroids (ANS) on the need for blood pressure support in extremely premature infants. METHODS: Extremely premature infants with gestational age of 24 to 28 weeks were included in this study during a 5-year period. The main outcome measure of the study was the amount of blood pressure support during the first 3 days of life. RESULTS: The study infants (n = 163) were divided into: infants not exposed (ANS; n = 27) and exposed to ANS (ANS; n = 136). Blood pressure support was significantly lower in ANS compared with No ANS (65% vs 96%; p = 0.003) and in single course (SANS; n = 73) and >or=2 courses (MANS; n = 34) compared with partial course of ANS (PANS; n = 29) (62%, 56% vs 86%; p = 0.03). The number of infants who received volume support and the amount of volume support were significantly lower in ANS compared with that in No ANS (p < 0.001) and in SANS and MANS compared with that in PANS (p < 0.02). CONCLUSION: Exposure to multiple courses of ANS was as beneficial as single course of ANS in decreasing the need for blood pressure support in extremely premature infants.
Authors:
G V Nair; S A Omar
Publication Detail:
Type:  Journal Article     Date:  2009-06-04
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  98     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-13     Completed Date:  2009-10-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1437-43     Citation Subset:  IM    
Affiliation:
Department of Pediatrics and Human Development, College Of Human Medicine, Michigan State University, East Lansing, MI 48909-7980, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / administration & dosage*,  therapeutic use
Analysis of Variance
Blood Pressure / drug effects*
Chi-Square Distribution
Dose-Response Relationship, Drug
Female
Gestational Age
Humans
Infant, Newborn
Infant, Premature
Logistic Models
Male
Obstetric Labor, Premature / drug therapy*
Outcome Assessment (Health Care)
Pregnancy
Prospective Studies
Retrospective Studies
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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